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Showing 1–9 of 9 results
Advanced filters: Author: Sílvia Osuna Clear advanced filters

  • Directed evolution of the final enzyme in the lovastatin biosynthetic pathway yields a variant with 29 mutations that does not require a carrier protein and displays altered dynamics of the catalytic residues, spending more time in the catalytically active conformation.

    • Gonzalo Jiménez-Osés
    • Sílvia Osuna
    • K N Houk
    Research
    Nature Chemical Biology
    Volume: 10, P: 431-436

  • Connecting conformational dynamics and epistasis has so far been limited to a few proteins and a single fitness trait. Here, the authors provide evidence of positive epistasis on multiple catalytic traits in the evolution and dynamics of engineered cytochrome P450 monooxygenase, offering insights for in silico protein design.

    • Carlos G. Acevedo-Rocha
    • Aitao Li
    • Manfred T. Reetz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Self-propulsion of biocatalytic micro- and nanomotors is facilitated by enzymes converting substrates into products. Here, the authors show that intrinsic enzymatic properties such as conformational changes are crucial for the self-propulsion of silica microcapsules modified with urease.

    • Xavier Arqué
    • Adrian Romero-Rivera
    • Samuel Sánchez
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Reductive desymmetrization of 2,2-disubstituted cyclodiketones can provide valuable complex molecules with multiple chiral centres, but the generation of a single stereoisomer is difficult. This work addresses this synthetic challenge by engineering the activity and stereoselectivity of a carbonyl reductase.

    • Xi Chen
    • Hongliu Zhang
    • Yanhe Ma
    Research
    Nature Catalysis
    Volume: 2, P: 931-941

  • Mixtures of various size fullerenes are available as a component of fullerene soot, but isolating pure fullerenes is a challenging task. Here, the authors use a porphyrin-based supramolecular cage that encapsulates fullerenes with high selectivity and releases C60by a simple washing technique.

    • Cristina García-Simón
    • Marc Garcia-Borràs
    • Xavi Ribas
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • In the Big Data era, a change of paradigm in the use of molecular dynamics is required. Trajectories should be stored under FAIR (findable, accessible, interoperable and reusable) requirements to favor its reuse by the community under an open science paradigm.

    • Rommie E. Amaro
    • Johan Åqvist
    • Modesto Orozco
    Comments & Opinion
    Nature Methods
    Volume: 22, P: 641-645

  • The stress-activated kinase p38γ has a role in regulating entry into the cell cycle; in the liver, it can induce cellular proliferation during regeneration and promote the development of hepatocellular carcinoma.

    • Antonia Tomás-Loba
    • Elisa Manieri
    • Guadalupe Sabio
    Research
    Nature
    Volume: 568, P: 557-560

  • In this Primer, Flitsch and colleagues describe how biocatalysis is facilitating synthetic chemistry in both academia and industry. Detailed considerations required to find, select and optimize a biocatalyst are described, followed by an analysis of the performance metrics used to define a good industrial catalyst.

    • Elizabeth L. Bell
    • William Finnigan
    • Sabine L. Flitsch
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-21