Locally advanced breast cancer (LABC) constitutes a heterogeneous entity that includes advanced-stage primary tumours, cancers with extensive nodal involvement and inflammatory breast carcinomas—inoperable cancers with an unfavourable prognosis. The optimal management of LABC requires a multidisciplinary approach consisting of a well-coordinated treatment schedule and close cooperation between medical, surgical and radiation oncologists. In this Review, the authors discuss the current state of the art and possible future treatment strategies for patients with LABC.
- Konstantinos Tryfonidis
- Elzbieta Senkus
- Fatima Cardoso
