Nature Search

Trickle Perfusion for Organ Preservation

R. Y. CALNE
D. C. DUNN
A. J. ROBSON
Research21 Jan 1972
Nature

Volume: 235, P: 171-173
Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation

Gastrointestinal motility disorders affect over 20% of the population, yet current therapies provide limited relief. Here, the authors show that in a swine model a closed-loop GI neuroprosthesis restores peristalsis and enhances metabolic responses via targeted electrical and chemical stimulation

Shriya Srinivasan
Marc-Joseph Antonini
Giovanni Traverso
ResearchOpen Access10 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Spin Echo Studies on Cellular Water

D. C. CHANG
C. F. HAZLEWOOD
H. E. RORSCHACH
Research21 Jan 1972
Nature

Volume: 235, P: 170-171
Preservation of Vascular Integrity in Organs perfused in vitro with a Platelet-rich Medium

MICHAEL A. GIMBRONE jun.
RICHARD H. ASTER
JUDAH FOLKMAN
Research05 Apr 1969
Nature

Volume: 222, P: 33-36
Limitations of Electronic Interpretations of Chemical Phenomena

C. R. ALLEN
P. G. WRIGHT
Research27 Jul 1963
Nature

Volume: 199, P: 344-346
Enzymatic conversion of human blood group A kidneys to universal blood group O

ABO blood group compatibility restrictions limit the availability of organs for patients awaiting transplantation. Here, the authors show the rapid enzymatic removal of blood group A antigens from the vasculature of human kidneys using normothermic and hypothermic machine perfusion technologies to make universal blood group O organs for transplantation.

Serena MacMillan
Sarah A. Hosgood
Michael L. Nicholson
ResearchOpen Access30 Mar 2024
Nature Communications

Volume: 15, P: 1-14
APOE–NOTCH axis governs elastogenesis during human cardiac valve remodeling

Z. Liu, Y. Liu and Z. Yu et al. discovered a subtype of valve interstitial cells underneath the valve endothelial cells sensing unidirectional flow. These cells express high levels of APOE, which is responsible for JAG1–NOTCH2-mediated fetal elastogenesis.

Ziyi Liu
Yu Liu
Mingxia Gu
Research24 Jul 2024
Nature Cardiovascular Research

Volume: 3, P: 933-950
Long-term ex situ normothermic perfusion of human split livers for more than 1 week

Long-term machine perfusion of human livers outside the body is an emerging field with tremendous potential for the assessment, recovery, and modification of organs prior to transplantation. Here, the authors report the long-term ex situ perfusion of human livers and demonstrate the ability to split and perfuse these organs using a standardised protocol.

Ngee-Soon Lau
Mark Ly
Carlo Pulitano
ResearchOpen Access08 Aug 2023
Nature Communications

Volume: 14, P: 1-11
Functional Preservation of Canine Heart–Lung Preparations by Perfusion with Pure Haemoglobin Solution

W. M. RIEDESEL II
I. ERDAMAR
S. J. DOS
Research29 Jun 1973
Nature

Volume: 243, P: 530-531
Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation

Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important. This study introduces human liver ex situ normothermic perfusion as a model to evaluate gene therapy vectors, paving the way for advanced liver disease treatment.

Marti Cabanes-Creus
Sophia H. Y. Liao
Leszek Lisowski
ResearchOpen Access14 Mar 2024
Nature Communications

Volume: 15, P: 1-15
Cells of the human intestinal tract mapped across space and time

Cells from embryonic, fetal, paediatric and adult human intestinal tissue are analysed at different locations along the intestinal tract to construct a single-cell atlas of the developing and adult human intestinal tract, encompassing all cell lineages.

Rasa Elmentaite
Natsuhiko Kumasaka
Sarah A. Teichmann
ResearchOpen Access08 Sept 2021
Nature

Volume: 597, P: 250-255
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

Spatial transcriptomics and single-cell profiling identify previously uncharacterized cell types of human terminal and respiratory bronchioles, and show that cell differentiation and lineage trajectories are distinct from those in the mouse lung.

Preetish Kadur Lakshminarasimha Murthy
Vishwaraj Sontake
Purushothama Rao Tata
Research30 Mar 2022
Nature

Volume: 604, P: 111-119
Mutant clones in normal epithelium outcompete and eliminate emerging tumours

The rarity of tumour formation despite the high proportion of cancer-driver mutations in epithelia is explained by the competitive fitness of tumour cells relative to that of surrounding mutant epithelial cells.

B. Colom
A. Herms
P. H. Jones
Research13 Oct 2021
Nature

Volume: 598, P: 510-514
A cellular census of human lungs identifies novel cell states in health and in asthma

Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4⁺ T cells, in asthmatic lungs

Felipe A. Vieira Braga
Gozde Kar
Sarah A. Teichmann
Research17 Jun 2019
Nature Medicine

Volume: 25, P: 1153-1163
Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation

J. Ryan Gunsalus
Deborah A. Brady
Albert S.B. Edge
Research01 Jan 1997
Nature Medicine

Volume: 3, P: 48-53
Tubular Transport by Human Kidney stored at 4°C

STANTON SEGAL
INEZ SMITH
PHILIP HOLTZAPPLE
Research26 Apr 1969
Nature

Volume: 222, P: 387-389
The Influence of Increased Renal Mass on Cardiovascular Function in Immature Dogs

William J H Caldicott
Julie R Ingelfinger
Research01 Jun 1981
Pediatric Research

Volume: 15, P: 935-939
The Adaptation of Hydrogen Ion Excretion Associated with Nephron Reduction in Post-transplant Patients

James C M Chan
Carl M Grushkin
Richard N Fine
Research01 Aug 1973
Pediatric Research

Volume: 7, P: 712-718
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

Analysis of T cells isolated from patients with and without type 1 diabetes reveals reactivity to a range of native as well as post-translationally modified self-antigens only in individuals with T1D.

Jenny Aurielle B Babon
Megan E DeNicola
Sally C Kent
Research31 Oct 2016
Nature Medicine

Volume: 22, P: 1482-1487
Successful liquid storage of peripheral blood stem cells at subzero non-freezing temperature

N Matsumoto
H Yoshizawa
F Gejyo
Research14 Nov 2002
Bone Marrow Transplantation

Volume: 30, P: 777-784
Extended supercooled storage of red blood cells

This study explores the premise of extended – up to 23 weeks – supercooled storage of human red blood cells in modern and traditional hypothermic additive solutions and the impact of antioxidant supplementation, in comparison to hypothermic storage.

Ziya Isiksacan
Nishaka William
O. Berk Usta
ResearchOpen Access24 Jun 2024
Communications Biology

Volume: 7, P: 1-9
Postbiotics — when simplification fails to clarify

José Eleazar Aguilar-Toalá
Stefania Arioli
Zhigang Zhou
Correspondence23 Sept 2021
Nature Reviews Gastroenterology & Hepatology

Volume: 18, P: 825-826
Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung

Tristan Frum
Peggy P. Hsu
Jason R. Spence
ResearchOpen Access09 Sept 2023
npj Regenerative Medicine

Volume: 8, P: 1-19
Multi-omics approach identifies gut microbiota variations associated with depression

Adrián Hernández-Cacho
Jesús F. García-Gavilán
Jordi Salas-Salvadó
ResearchOpen Access28 Apr 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-12
Production of an interleukin-10 blocking antibody by genetically engineered macrophages increases cancer cell death in human gastrointestinal tumor slice cultures

Kevin P. Labadie
Shannon A. Kreuser
Venu G. Pillarisetty
Research09 Jun 2023
Cancer Gene Therapy

Volume: 30, P: 1227-1233
Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Monique M. A. Verstegen
Floris J. M. Roos
Luc J. W. van der Laan
ResearchOpen Access14 Dec 2020
Scientific Reports

Volume: 10, P: 1-16
Aggravation of fibrin deposition and microthrombus formation within the graft during kidney transplantation

Tamar A. J. van den Berg
Marius C. van den Heuvel
Robert A. Pol
ResearchOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-11
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice

Pingping Ren
Michael Hughes
Ying H. Shen
ResearchOpen Access27 Sept 2017
Scientific Reports

Volume: 7, P: 1-14
Association between myelodysplastic syndromes and inflammatory bowel diseases. Report of seven new cases and review of the literature

M Hebbar
D Kozlowski
P Fenaux
Research01 Dec 1997
Leukemia

Volume: 11, P: 2188-2191
Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract

C de Martel
M Plummer
S Franceschi
ResearchOpen Access25 Nov 2008
British Journal of Cancer

Volume: 100, P: 194-199
Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense

Jannie G. E. Henderickx
Romy D. Zwittink
Clara Belzer
ResearchOpen Access17 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome

Diana M. Hendrickx
Ran An
Clara Belzer
ResearchOpen Access25 Jul 2023
Scientific Reports

Volume: 13, P: 1-18
Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder

Simone Zuffa
Patrick Schimmel
Rochellys Diaz Heijtz
ResearchOpen Access13 Jul 2023
Translational Psychiatry

Volume: 13, P: 1-10
A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result

M J Donovan
M Noerholm
G A Brown
Research08 Sept 2015
Prostate Cancer and Prostatic Diseases

Volume: 18, P: 370-375
Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

Shanthadevi Udayappan
Louise Manneras-Holm
Max Nieuwdorp
ResearchOpen Access06 Jul 2016
npj Biofilms and Microbiomes

Volume: 2, P: 1-10

Search

Trickle Perfusion for Organ Preservation

Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation

Spin Echo Studies on Cellular Water

Preservation of Vascular Integrity in Organs perfused in vitro with a Platelet-rich Medium

Limitations of Electronic Interpretations of Chemical Phenomena

Enzymatic conversion of human blood group A kidneys to universal blood group O

APOE–NOTCH axis governs elastogenesis during human cardiac valve remodeling

Long-term ex situ normothermic perfusion of human split livers for more than 1 week

Functional Preservation of Canine Heart–Lung Preparations by Perfusion with Pure Haemoglobin Solution

Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation

Cells of the human intestinal tract mapped across space and time

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

Mutant clones in normal epithelium outcompete and eliminate emerging tumours

A cellular census of human lungs identifies novel cell states in health and in asthma

Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation

Tubular Transport by Human Kidney stored at 4°C

The Influence of Increased Renal Mass on Cardiovascular Function in Immature Dogs

The Adaptation of Hydrogen Ion Excretion Associated with Nephron Reduction in Post-transplant Patients

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

Successful liquid storage of peripheral blood stem cells at subzero non-freezing temperature

Extended supercooled storage of red blood cells

Postbiotics — when simplification fails to clarify

Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung

Multi-omics approach identifies gut microbiota variations associated with depression

Production of an interleukin-10 blocking antibody by genetically engineered macrophages increases cancer cell death in human gastrointestinal tumor slice cultures

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Aggravation of fibrin deposition and microthrombus formation within the graft during kidney transplantation

Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice

Association between myelodysplastic syndromes and inflammatory bowel diseases. Report of seven new cases and review of the literature

Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract

Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense

Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome

Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder

A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

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