Nature Search

Implementation of an asthma guideline for the management of childhood asthma in general practice: a randomised controlled trial

Wanda Hagmolen of ten Have
Norbert J van den Berg
Patrick JE Bindels
Research12 Mar 2008
Primary Care Respiratory Journal

Volume: 17, P: 90-96
Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2

Marieke Mastop
Daphne S. Bindels
Joachim Goedhart
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-18
‘Am I going to see the next morning?’ A qualitative study of patients' perspectives of sleep in COPD

Bryanie S Shackell
Rupert CM Jones
John Campbell
Research21 Dec 2007
Primary Care Respiratory Journal

Volume: 16, P: 378-383
Prescribing of asthma medication in primary care for children aged under 10

Siebrig Schokker
Feikje Groenhof
Thys van der Molen
Research06 Aug 2009
Primary Care Respiratory Journal

Volume: 19, P: 28-34
Adult human kidney organoids originate from CD24⁺ cells and represent an advanced model for adult polycystic kidney disease

Adult kidney organoids, or tubuloids, originate from CD24⁺ epithelial cells. Tubuloids represent a functional kidney tubule and can be used to model autosomal dominant polycystic kidney disease and study drug response.

Yaoxian Xu
Christoph Kuppe
Rafael Kramann
Research27 Oct 2022
Nature Genetics

Volume: 54, P: 1690-1701
Spatial multi-omic map of human myocardial infarction

A time-resolved high-resolution map of human cardiac remodelling after myocardial infarction, integrating single-cell transcriptomic, chromatin accessibility and spatial transcriptomic data, provides a valuable resource for the field.

Christoph Kuppe
Ricardo O. Ramirez Flores
Rafael Kramann
Research10 Aug 2022
Nature

Volume: 608, P: 766-777
Decoding myofibroblast origins in human kidney fibrosis

A range of techniques are used to investigate the molecular landscape of chronic kidney disease, and the results suggest that distinct populations of pericytes and fibroblasts are the main source of myofibroblasts in kidney fibrosis.

Christoph Kuppe
Mahmoud M. Ibrahim
Rafael Kramann
Research11 Nov 2020
Nature

Volume: 589, P: 281-286
Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

There is concern about potential long-term effects of antibiotics on children’s health. Here Leclercqet al. show, in mice, that low doses of penicillin during late pregnancy and early life induce lasting effects on the offspring, including alterations in gut microbiota, brain cytokine levels and behaviour.

Sophie Leclercq
Firoz M. Mian
John Bienenstock
ResearchOpen Access04 Apr 2017
Nature Communications

Volume: 8, P: 1-12
Multiparameter screening method for developing optimized red-fluorescent proteins

This protocol describes a screening pipeline to select red fluorescent proteins (FPs) with optimized parameters from a mutant FP library. FPs are screened for fluorescence lifetime, cellular brightness, maturation efficiency, and photostability.

Daphne S. Bindels
Marten Postma
Theodorus W. J. Gadella Jr
Protocols15 Jan 2020
Nature Protocols

Volume: 15, P: 450-478
Exhaled nitric oxide measures allergy not symptoms in children with allergic rhinitis in primary care: a prospective cross-sectional and longitudinal cohort study

Cindy MA de Bot
Heleen Moed
Johannes C van der Wouden
Research22 Jan 2013
Primary Care Respiratory Journal

Volume: 22, P: 44-50
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer

Defective DNA interstrand crosslink repair in Fanconi anaemia drives extensive genomic rearrangements, thereby substantially increasing the risk of cancer development.

Andrew L. H. Webster
Mathijs A. Sanders
Agata Smogorzewska
Research30 Nov 2022
Nature

Volume: 612, P: 495-502
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

Multi-omics analyses of faecal samples from patients with ulcerative colitis reveal a link between Bacteroides vulgatus protease activity and severity of disease symptoms.

Robert H. Mills
Parambir S. Dulai
David J. Gonzalez
Research27 Jan 2022
Nature Microbiology

Volume: 7, P: 262-276
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

A fluorescence-based sensor of PKA activity has increased brightness, dynamic range and signal-to-noise ratio over related sensors and is useful for visualizing kinase activity in HeLa cells, primary neurons and the cortex of awake mice.

Jin-Fan Zhang
Bian Liu
Jin Zhang
Research28 Sept 2020
Nature Chemical Biology

Volume: 17, P: 39-46
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

With the continued interest in the role of the gut microbiota in health, attention has now turned to how to harness the microbiota for the benefit of the host. This Consensus Statement outlines the definition and scope of the term 'prebiotic' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in December 2016.

Glenn R. Gibson
Robert Hutkins
Gregor Reid
ReviewsOpen Access14 Jun 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 14, P: 491-502
mScarlet: a bright monomeric red fluorescent protein for cellular imaging

An extremely bright, truly monomeric RFP, mScarlet, is described that outperforms existing RFPs in diverse labeling applications, especially in FRET with ratiometric imaging.

Daphne S Bindels
Lindsay Haarbosch
Theodorus W J Gadella Jr
Research21 Nov 2016
Nature Methods

Volume: 14, P: 53-56
Novel protocol for mapping virus integration sites in genes involved in therapy resistance

Michele Massimino
Zhangzan Huang
Maurice P. H. M. Jansen
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
The role of transient receptor potential channels in kidney disease

The transient receptor potential (TRP) is a protein superfamily whose members include 28 proteins known to be expressed in humans. Several TRPs are also expressed along the human nephron, and Titia Woudenberg-Vrenken and her colleagues discuss the evidence on the function of these renal TRPs and the possible relationship between channel or channel-regulation dysfunction and disease.

Titia E. Woudenberg-Vrenken
René J. M. Bindels
Joost G. J. Hoenderop
Reviews23 Jun 2009
Nature Reviews Nephrology

Volume: 5, P: 441-449
Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients

M Stendahl
Å Kronblad
G Landberg
ResearchOpen Access27 Apr 2004
British Journal of Cancer

Volume: 90, P: 1942-1948
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter

Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.

Jing Wang
Chongxiu Sun
Guo-Ping Shi
Research22 Jun 2015
Nature Medicine

Volume: 21, P: 820-826
Fast reversibly photoswitching red fluorescent proteins for live-cell RESOLFT nanoscopy

Bright reversibly switching red fluorescent proteins (rsFusionReds) with fast switching kinetics and low fatigue enable RESOLFT and MoNaLISA nanoscopy of live cells with green-orange illumination, which further reduces the risk of phototoxicity.

Francesca Pennacchietti
Ekaterina O. Serebrovskaya
Ilaria Testa
Research09 Jul 2018
Nature Methods

Volume: 15, P: 601-604
Tissue microarray analyses of G1/S-regulatory proteins in ductal carcinoma in situ of the breast indicate that low cyclin D1 is associated with local recurrence

K Jirström
A Ringberg
G Landberg
ResearchOpen Access11 Nov 2003
British Journal of Cancer

Volume: 89, P: 1920-1926
p15 ^INK4b in bladder carcinomas: decreased expression in superficial tumours

M A Le Frère-Belda
D Cappellen
F Radvanyi
ResearchOpen Access13 Nov 2001
British Journal of Cancer

Volume: 85, P: 1515-1521
Technology and its role in respiratory care

Sheree M Smith
Sarah L Elkin
Martyn R Partridge
Reviews08 Jul 2009
Primary Care Respiratory Journal

Volume: 18, P: 159-164
The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis

Christiaan J. Stavast
Iris van Zuijen
Stefan J. Erkeland
ResearchOpen Access05 Nov 2021
Leukemia

Volume: 36, P: 687-700
The prognostic impact of NF-κB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer

S Al-Saad
K Al-Shibli
L-T Busund
ResearchOpen Access14 Oct 2008
British Journal of Cancer

Volume: 99, P: 1476-1483
Influence of Long Chain Unsaturated Fatty Acids in Formula Feeds on Lipid Peroxidation and Antioxidants in Preterm Infants

N J M Jacobs
D Van Zoeren-Grobben
H M Berger
Research01 Nov 1996
Pediatric Research

Volume: 40, P: 680-686
Bile acids and the gut microbiota: metabolic interactions and impacts on disease

The gut microbiota metabolizes bile acids, thereby influencing human health and diseases including obesity, colitis and cancer. In this Review, Patterson and colleagues discuss host–microbiota interactions and their influence on the bile acid pool as well as therapeutic implications.

Stephanie L. Collins
Jonathan G. Stine
Andrew D. Patterson
Reviews17 Oct 2022
Nature Reviews Microbiology

Volume: 21, P: 236-247
Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score

Lonneke B van der Mark
Karina E van Wonderen
Patrick JE Bindels
Research05 Feb 2014
Primary Care Respiratory Journal

Volume: 23, P: 52-59
Archived bone marrow smears are an excellent source for NGS-based mutation detection in acute myeloid leukemia

Adil S. A. Al Hinai
Tim Grob
Peter J. M. Valk
Research14 Feb 2020
Leukemia

Volume: 34, P: 2220-2224
‘Under pressure’: how Ghanaian, African-Surinamese and Dutch patients explain hypertension

E J A J Beune
J A Haafkens
P J E Bindels
Research19 Oct 2006
Journal of Human Hypertension

Volume: 20, P: 946-955
Regulation of vimentin by SIP1 in human epithelial breast tumor cells

S Bindels
M Mestdagt
C Gilles
Research27 Mar 2006
Oncogene

Volume: 25, P: 4975-4985
Aberrant expression of miR-9/9* in myeloid progenitors inhibits neutrophil differentiation by post-transcriptional regulation of ERG

K Nowek
S M Sun
M Jongen-Lavrencic
Research15 Jul 2015
Leukemia

Volume: 30, P: 229-237
Fhit regulates invasion of lung tumor cells

A Joannes
A Bonnomet
B Nawrocki-Raby
Research23 Nov 2009
Oncogene

Volume: 29, P: 1203-1213
Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs

S Chen
N A Zambetti
M H G P Raaijmakers
CorrespondenceOpen Access25 Apr 2016
Leukemia

Volume: 30, P: 1938-1942
A systematic review of questionnaires measuring asthma control in children in a primary care population

Sara Bousema
Arthur M. Bohnen
Gijs Elshout
ReviewsOpen Access11 Jul 2023
npj Primary Care Respiratory Medicine

Volume: 33, P: 1-9

Search

Implementation of an asthma guideline for the management of childhood asthma in general practice: a randomised controlled trial

Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2

‘Am I going to see the next morning?’ A qualitative study of patients' perspectives of sleep in COPD

Prescribing of asthma medication in primary care for children aged under 10

Adult human kidney organoids originate from CD24⁺ cells and represent an advanced model for adult polycystic kidney disease

Spatial multi-omic map of human myocardial infarction

Decoding myofibroblast origins in human kidney fibrosis

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

Multiparameter screening method for developing optimized red-fluorescent proteins

Exhaled nitric oxide measures allergy not symptoms in children with allergic rhinitis in primary care: a prospective cross-sectional and longitudinal cohort study

Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

mScarlet: a bright monomeric red fluorescent protein for cellular imaging

Novel protocol for mapping virus integration sites in genes involved in therapy resistance

The role of transient receptor potential channels in kidney disease

Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients

Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter

Fast reversibly photoswitching red fluorescent proteins for live-cell RESOLFT nanoscopy

Tissue microarray analyses of G1/S-regulatory proteins in ductal carcinoma in situ of the breast indicate that low cyclin D1 is associated with local recurrence

p15 ^INK4b in bladder carcinomas: decreased expression in superficial tumours

Technology and its role in respiratory care

The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis

The prognostic impact of NF-κB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer

Influence of Long Chain Unsaturated Fatty Acids in Formula Feeds on Lipid Peroxidation and Antioxidants in Preterm Infants

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score

Archived bone marrow smears are an excellent source for NGS-based mutation detection in acute myeloid leukemia

‘Under pressure’: how Ghanaian, African-Surinamese and Dutch patients explain hypertension

Regulation of vimentin by SIP1 in human epithelial breast tumor cells

Aberrant expression of miR-9/9* in myeloid progenitors inhibits neutrophil differentiation by post-transcriptional regulation of ERG

Fhit regulates invasion of lung tumor cells

Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs

A systematic review of questionnaires measuring asthma control in children in a primary care population

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