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Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue

Enhancing thermogenesis is a promising therapeutic strategy for promoting metabolic health. Here the authors show that adipocyte-secreted BMP8b contributes to optimizing the thermogenic response by remodeling of the neuro-vascular networks in brown and white adipose tissue.

Vanessa Pellegrinelli
Vivian J. Peirce
Antonio Vidal-Puig
ResearchOpen Access26 Nov 2018
Nature Communications

Volume: 9, P: 1-18
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

Stig E Bojesen
Karen A Pooley
Alison M Dunning
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 371-384
Author Correction: High- or low-dose preoperative ipilimumab plus nivolumab in stage III urothelial cancer: the phase 1B NABUCCO trial

Jeroen van Dorp
Christodoulos Pipinikas
Michiel S. van der Heijden
Amendments and Corrections17 Jul 2023
Nature Medicine

Volume: 30, P: 304
High- or low-dose preoperative ipilimumab plus nivolumab in stage III urothelial cancer: the phase 1B NABUCCO trial

High-dose ipilimumab plus nivolumab in locoregionally advanced urothelial cancer led to a higher pathological complete response rate than low-dose ipilimumab in cohort 2. Presurgical absence of plasma (but not urinary) circulating tumor DNA correlated with clinical outcome.

Jeroen van Dorp
Christodoulos Pipinikas
Michiel S. van der Heijden
Research02 Feb 2023
Nature Medicine

Volume: 29, P: 588-592
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

Douglas Easton and colleagues report results of a large multistage genome-wide association study of breast cancer. The study identifies two new breast cancer risk loci on chromosomes 3p24 and 17q23.2.

Shahana Ahmed
Gilles Thomas
Douglas F Easton
Research29 Mar 2009
Nature Genetics

Volume: 41, P: 585-590
Genome-wide association analysis identifies three new breast cancer susceptibility loci

Douglas Easton and colleagues report a genome-wide association analyses for breast cancer in ~70,000 cases and ~68,000 controls. They identify three new breast cancer susceptibility loci, two of which show association only with estrogen receptor–positive disease.

Maya Ghoussaini
Olivia Fletcher
Douglas F Easton
Research22 Jan 2012
Nature Genetics

Volume: 44, P: 312-318
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

Neoadjuvant immunotherapy combination in the NABUCCO trial elicits high pathological complete response rates in patients with locoregionally advanced (stage III) urothelial cancer and provides molecular biomarkers of treatment efficacy.

Nick van Dijk
Alberto Gil-Jimenez
Michiel S. van der Heijden
Research12 Oct 2020
Nature Medicine

Volume: 26, P: 1839-1844
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Richard Houlston and colleagues report results of a genome-wide association study of Hodgkin's lymphoma. They identify three new susceptibility loci at 2p16 (REL), 8q24 and 10p14 (GATA3) and confirm a strong role for the HLA region in disease etiology.

Victor Enciso-Mora
Peter Broderick
Richard S Houlston
Research31 Oct 2010
Nature Genetics

Volume: 42, P: 1126-1130
Social activity and relationship changes experienced by people with bowel and bladder dysfunction following spinal cord injury

S Braaf
A Lennox
B Gabbe
Research28 Feb 2017
Spinal Cord

Volume: 55, P: 679-686
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Hatef Darabi
Jonathan Beesley
Alison M. Dunning
ResearchOpen Access07 Sept 2016
Scientific Reports

Volume: 6, P: 1-14

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Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Author Correction: High- or low-dose preoperative ipilimumab plus nivolumab in stage III urothelial cancer: the phase 1B NABUCCO trial

High- or low-dose preoperative ipilimumab plus nivolumab in stage III urothelial cancer: the phase 1B NABUCCO trial

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

Genome-wide association analysis identifies three new breast cancer susceptibility loci

Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Social activity and relationship changes experienced by people with bowel and bladder dysfunction following spinal cord injury

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

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