Nature Search

Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies

GBA, a major gene for Parkinson’s disease and dementia with Lewy bodies, is associated with increased risk of developing dementia. Here, we demonstrate that GBA mutations in mice contribute to cognitive deficits through α-synuclein-independent mechanisms that impact synaptic vesicle endocytosis.

D. J. Vidyadhara
David Bäckström
Sreeganga. S. Chandra
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Double burden of malnutrition among urban Bengalee adolescent boys in Midnapore, West Bengal, India

S Bisai
R Khongsdier
D Mahalanabis
ResearchOpen Access03 Apr 2012
Nature Precedings

P: 1
Double burden of malnutrition among urban Bengalee adolescent boys in Midnapore, West Bengal, India

S Bisai
R Khongsdier
D Mahalanabis
ResearchOpen Access03 Apr 2012
Nature Precedings

P: 1
Combatting virulent gut bacteria by inhibiting the biosynthesis of a two-component lanthipeptide toxin

The enterococcal cytolysin is a two-component toxin that is responsible for a fatal form of alcoholic hepatitis. Here, authors used knowledge of the toxin’s biosynthesis to develop small molecule inhibitors of toxin production.

Ryan Moreira
Bidisha Chakraborty
Wilfred A. van der Donk
ResearchOpen Access28 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Evaluating individual and mixed arbuscular mycorrhizal fungi for controlling Rhizoctonia root rot in lupine

Marwa A. M. Atwa
Sozan E. El-Abeid
Salama A. S. El-Blasy
ResearchOpen Access07 Oct 2025
Scientific Reports

Volume: 15, P: 1-12
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Capturing rapid nanomaterial transformations with cross-platform operando characterization

The inability to observe the rapid, initial transformations that dictate nanomaterial fate constitutes a fundamental scientific gap, forcing risk assessments to rely on retrospective, incomplete data. A paradigm shift to real-time, operando characterization is vital to build the predictive understanding required for the development of safe and sustainable nanomaterials and applications.

Swaroop Chakraborty
Superb K. Misra
Iseult Lynch
Comments & Opinion30 Sept 2025
Nature Reviews Materials

P: 1-3
Single-cell transcriptomics of ventral forebrain progenitors identifies Evf2 enhancer lncRNA-enhancer gene guidance through direct RNA binding and RNP recruitment domains

Enhancer-gene selectivity establishes gene expression networks during development. Here, the authors link Evf2 enhancer-gene guidance and seizure gene regulation, Evf2 RNA binding sites and chromosomal RNP recruitment domains, and homeodomain motif recognition to support multilayered mechanisms.

Edward Li
Abhijit Chakraborty
Jhumku D. Kohtz
ResearchOpen Access26 Jul 2025
Nature Communications

Volume: 16, P: 1-23
Understanding Genomic Evolution of Olfactory Receptors through Fractal and Mathematical Morphology

Sk. Sarif Hassan
Pabitra Pal Choudhury
Arunava Goswami
ResearchOpen Access14 Feb 2011
Nature Precedings

P: 1
Expression of Green Fluorescence Protein (GFP) in Zebrafish Muscle through Injection: A Gene Therapy Model

C. S. Lin
Jhen Ru Shih
Chiranjib Chakraborty
ResearchOpen Access28 Dec 2008
Nature Precedings

P: 1
Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829
Observations of reverse polarity flux transfer events at the Earth's dayside magnetopause

R. P. Rijnbeek
S. W. H. Cowley
C. T. Russell
Research04 Nov 1982
Nature

Volume: 300, P: 23-26
Structural origin of fracture-induced surface charges in piezoelectric pharmaceutical crystals for engineering bulk properties

Surface charging in crystalline materials is a complex phenomenon to predict and design. Here the authors show the origin of surface charges in polar piezoelectric pharmaceuticals to predict the outcome of mechanical impact on their bulk properties.

Kaustav Das
Ishita Ghosh
C. Malla Reddy
ResearchOpen Access25 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Multimodal gradients of basal forebrain connectivity across the neocortex

The basal forebrain innervates the cortex with cholinergic projections via long-range branching projections. Using MRI and PET, the authors show that these projections exhibit gradients of increasing branch complexity traversing unimodal to transmodal cortex.

Sudesna Chakraborty
Roy A. M. Haast
Taylor W. Schmitz
ResearchOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1-16
LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer

Shengkai Chen
Zhenlin Dai
Qin Xu
ResearchOpen Access12 Sept 2025
International Journal of Oral Science

Volume: 17, P: 1-16
Partners in root nodule symbiosis respond uniquely to heavy metal stresses in a host genotype-dependent manner

Sanhita Chakraborty
Reena Sharma
Timothy Paape
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-17
Polyglutamylation of microtubules drives neuronal remodeling

Cytoskeletal breakdown is a hallmark of synapse elimination. Here, the authors show that a post-translational modification on microtubules encodes activity-dependent signals instructing neuronal remodeling in the central and peripheral nervous system.

Antoneta Gavoci
Anxhela Zhiti
Monika S. Brill
ResearchOpen Access25 Jun 2025
Nature Communications

Volume: 16, P: 1-17
Genetic Analysis of ABO and Rh Blood Groups in Brahmin Population of Uttar Pradesh, India”

Vandana Rai
ResearchOpen Access02 May 2011
Nature Precedings

P: 1
Tight linkage between a splicing mutation and a specific DNA haplotype in phenylketonuria

Anthony G. DiLella
Joshua Marvit
Savio L. C. Woo
Research28 Aug 1986
Nature

Volume: 322, P: 799-803
Proteomics in the Light of Integral Value Transformations

Sk. S. Hassan
P. Pal Choudhury
ResearchOpen Access06 Jul 2011
Nature Precedings

P: 1
A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3

Hugh Watkins
Calum MacRae
Christine E. Seidman
Research01 Apr 1993
Nature Genetics

Volume: 3, P: 333-337
Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines

Lone B. Andersen
Jane W. Fountain
Francis S. Collins
Research01 Feb 1993
Nature Genetics

Volume: 3, P: 118-121
Mapping a gene for Noonan syndrome to the long arm of chromosome 12

C. Ruth Jamieson
Ineke van der Burgt
Edwin Mariman
Research01 Dec 1994
Nature Genetics

Volume: 8, P: 357-360
Perovskite nickelates as bio-electronic interfaces

Functional materials that act as bio-sensing media when interfaced with complex bio-matter are attractive for health sciences and bio-engineering. Here, the authors report room temperature enzyme-mediated spontaneous hydrogen transfer between a perovskite quantum material and glucose reactions.

Hai-Tian Zhang
Fan Zuo
Shriram Ramanathan
ResearchOpen Access10 Apr 2019
Nature Communications

Volume: 10, P: 1-7
FYB-201 Biosimilar ranibizumab (Ongavia/Ranivisio/Cimerli) Efficacy and Safety in Clinical Settings – FORCE study

Ashish Sharma
Luke Nicholson
Judy E. Kim
Research02 Oct 2025
Eye

P: 1-6
Dejerine–Sottas syndrome associated with point mutation in the peripheral myelin protein 22 (PMP22) gene

Benjamin B. Roa
Peter J. Dyck
James R. Lupski
Research01 Nov 1993
Nature Genetics

Volume: 5, P: 269-273
The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling

Ras signalling activates the transcription factor c-Jun/AP-1, but the mechanism was unclear. Here, Chakraborty et al.describe a phosphorylation–ubiquitination cascade involving MSK1 and the E3 ubiquitin ligases Trim7 and RACO-1, which mediates c-Jun activation in Ras-driven lung tumorigenesis.

Atanu Chakraborty
Markus E. Diefenbacher
Axel Behrens
Research08 Apr 2015
Nature Communications

Volume: 6, P: 1-12
Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.

Benjamin T. Jackson
Angela M. Montero
Lydia W. S. Finley
Research28 Apr 2025
Nature Metabolism

Volume: 7, P: 1168-1182
Triggering the 2022 eruption of Mauna Loa

Distinguishing between periods of unrest and the run-up to eruption is a major challenge at volcanoes around the globe. Here, we leverage multidisciplinary data to show that the Mauna Loa 2022 eruption was caused by 2 months of magma intrusion.

Kendra J. Lynn
Drew T. Downs
Jefferson C. Chang
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-12
Small effect of water on upper-mantle rheology based on silicon self-diffusion coefficients

Measurements of the silicon self-diffusion coefficients in olivine at high temperature show that the effect of water content on rock deformation is actually very small, not large as was previously thought.

Hongzhan Fei
Michael Wiedenbeck
Tomoo Katsura
Research12 Jun 2013
Nature

Volume: 498, P: 213-215
Micro-magnetic resonance imaging (micro-MRI) study on the sepsis effected eyeball of zebrafish

Bimal Kumar Sarkar
Wu Zen
Chiranjib Chakraborty
ResearchOpen Access22 Dec 2008
Nature Precedings

P: 1
Replications, ridicule and a recluse: the controversy over NgAgo gene-editing intensifies

As failures to replicate results using the CRISPR alternative stack up, a quiet scientist stands by his claims.

David Cyranoski
News08 Aug 2016
Nature

Volume: 536, P: 136-137
Bayesian optimized CNN ensemble for efficient potato blight detection using fuzzy image enhancement

Achin Jain
Arun Kumar Dubey
Brij B. Gupta
ResearchOpen Access25 Aug 2025
Scientific Reports

Volume: 15, P: 1-20
Room-temperature valley coherence in a polaritonic system

Owing to the presence of strongly bound excitons and degenerate valleys, monolayer transition metal dichalcogenides show promise for valleytronic applications. Here, the authors embed monolayer WSe₂ in a monolithic dielectric cavity, and observe room-temperature valley coherence of valley-polaritons.

L. Qiu
C. Chakraborty
A. N. Vamivakas
ResearchOpen Access03 Apr 2019
Nature Communications

Volume: 10, P: 1-5
Precipitation isotopes and monsoon dynamics in the core monsoon zone of India

Supriyo Chakraborty
Aharna Sarkar
Anupam Sharma
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Discovery of extreme quasi-periodic eruptions in a newly accreting massive black hole

In February 2024, rapid, recurring X-ray bursts (quasi-periodic eruptions) were detected from the black hole within galaxy SDSS1335+0728. Named Ansky, the event features day-and-a-half-long flares and extreme energy levels, challenging existing models.

Lorena Hernández-García
Joheen Chakraborty
Belén Sotomayor
Research11 Apr 2025
Nature Astronomy

Volume: 9, P: 895-906
Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules

An icosahedral DNA nanocapsule with photoresponsive polymers that can deliver small molecules into model organisms with high spatial and temporal resolution.

Aneesh T. Veetil
Kasturi Chakraborty
Yamuna Krishnan
Research21 Aug 2017
Nature Nanotechnology

Volume: 12, P: 1183-1189
A numerical investigation to design and performance optimization of lead-free Cs₂TiCl₆based perovskite solar cells with different charge transport layers

Sahjahan Islam
M. Khalid Hossain
Rajesh Haldhar
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-20
Certified randomness using a trapped-ion quantum processor

Certifiably random bits can be generated using the 56-qubit Quantinuum H2-1 trapped-ion quantum computer accessed over the Internet.

Minzhao Liu
Ruslan Shaydulin
Marco Pistoia
ResearchOpen Access26 Mar 2025
Nature

Volume: 640, P: 343-348
Can phenotypic variability of polygenic traits yield information regarding selection?

G S Mani
Research01 Apr 1988
Heredity

Volume: 60, P: 193-195
Cell cycle control by timer and sizer in Chlamydomonas

Lorraine Donnan
Peter C. L. John
Research18 Aug 1983
Nature

Volume: 304, P: 630-633
Fixation of Nitrogen by the Rice Plant

S. P. CHAKRABORTY
S. P. SEN GUPTA
Research26 Dec 1959
Nature

Volume: 184, P: 2033-2034
Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential

Programed cell death occurs in a stereotypic fashion duringC. elegansdevelopment, and it is thought that engulfment promotes programmed cell death. Here the authors present evidence that a signaling function of the conserved engulfment pathways, not the process of engulfment itself, promotes apoptotic cell death.

Sayantan Chakraborty
Eric J. Lambie
Barbara Conradt
ResearchOpen Access10 Dec 2015
Nature Communications

Volume: 6, P: 1-9
Species Difference in the Biosynthesis of Vitamin C and Response to Diabetogenic Substances

M. C. NATH
C. H. CHAKRABORTY
KUSUM S. LAUL
Research23 Oct 1948
Nature

Volume: 162, P: 660-661
Suppression of stress granule formation is a vulnerability imposed by mutant p53

Mutations in the TP53 gene are linked to cancer progression and drug resistance. Here, the authors show that mutant p53 inhibits stress granule formation, leading to increased apoptosis and enhanced sensitivity to the ER stress-inducing chemotherapy drug sorafenib in preclinical models of hepatocellular carcinoma.

Elizabeth Thoenen
Atul Ranjan
Tomoo Iwakuma
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-17
Factors governing \({\rm H}_{3}^{+}\) formation from methyl halogens and pseudohalogens

The trihydrogen cation (H3+) plays a key role in the interstellar chemistry. Here the authors, using state of the art experiments and computation, identify factors that govern H3+ formation from doubly ionized small organic molecules, offering guidelines for examining alternative sources of H3+ in the universe.

Jacob Stamm
Swati S. Priyadarsini
Marcos Dantus
ResearchOpen Access06 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Large disagreements in estimates of urban land across scales and their implications

There has been a surge in global datasets of urban land recently. This paper shows large discrepancies in urban area across scales among multiple such datasets, which can influence the magnitude and direction of estimated urban climate impacts.

TC Chakraborty
Zander S. Venter
Yun Qian
ResearchOpen Access24 Oct 2024
Nature Communications

Volume: 15, P: 1-15
The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Non-resolving bacterial pneumonia results in lung tissue damage owing to overactive inflammation. Here the authors show that the mitochondrial DAMP cardiolipin contributes to persistent inflammation by SUMOylating PPARγ, which promotes binding of the corepressor NCOR/HDAC3 complex to the IL-10 promoter.

Krishnendu Chakraborty
Mahesh Raundhal
Prabir Ray
ResearchOpen Access11 Jan 2017
Nature Communications

Volume: 8, P: 1-15
Reproductive and genetic consequences of founding isolated lion populations

D. E. Wildt
M. Bush
S. J. O'Brien
Research24 Sept 1987
Nature

Volume: 329, P: 328-331
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Most adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair.

Anirban Chakraborty
Nisha Tapryal
Tapas K. Hazra
ResearchOpen Access05 Oct 2016
Nature Communications

Volume: 7, P: 1-12

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