MET tyrosine kinase has a central role in cell motility, proliferation and protection from apoptosis — properties that can transform it into a powerful pro-metastatic agent or oncogene. Here, Comoglio and colleagues discuss its biological role in cancer progression, recent progress in MET-targeted therapies, and how to identify the patient populations that might benefit from such treatment.
- Paolo M. Comoglio
- Silvia Giordano
- Livio Trusolino
