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British Journal of Cancer (20)
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Showing 1–50 of 82 results

Advanced filters: Author: S Higashiyama Clear advanced filters

Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value

M Higashiyama
O Doi
N Kimura
Research01 Sept 1992
British Journal of Cancer

Volume: 66, P: 533-536
MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation

M Higashiyama
O Doi
I Nishisho
Research01 May 1997
British Journal of Cancer

Volume: 75, P: 1302-1308
Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins

Chemical and mechanical cues coordinately regulate angiogenesis. Here, the authors show that blood flow-driven intraluminal pressure regulates wound angiogenesis. Findings indicate that TOCA family of F-BAR proteins act as actin regulators required for endothelial cell migration and sense mechanical cell stretching to regulate wound angiogenesis.

Shinya Yuge
Koichi Nishiyama
Shigetomo Fukuhara
ResearchOpen Access12 May 2022
Nature Communications

Volume: 13, P: 1-25
Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid cells

In this study, Higashiyama and colleagues examine pollen tube guidance in Torenia fournieri and identify the secreted guidance factors. These are cysteine-rich polypeptides belonging to the subgroup of defensin-like proteins (designated as LUREs), which are predominantly expressed in synergid cells and are required for pollen tube guidance.

Satohiro Okuda
Hiroki Tsutsui
Tetsuya Higashiyama
Research19 Mar 2009
Nature

Volume: 458, P: 357-361
Activated mesothelial cells produce heparin-binding growth factors: implications for tumour metastases

D G Jayne
S L Perry
P J Guillou
ResearchOpen Access22 Feb 2000
British Journal of Cancer

Volume: 82, P: 1233-1238
Morphology of Palaeospondylus shows affinity to tetrapod ancestors

Detailed structural analysis of Palaeospondylus gunni from the Middle Devonian period shows strong resemblance to Eusthenopteron and Panderichthys, indicating that it was a sarcopterygian and most probably a stem-tetrapod.

Tatsuya Hirasawa
Yuzhi Hu
Shigeru Kuratani
Research25 May 2022
Nature

Volume: 606, P: 109-112
Sex differences in the relationship between obesity and hypertension in Japan: a large population-based cross-sectional study

Tomomi Nagahata
Nagako Okuda
Akira Okayama
ResearchOpen Access19 Mar 2025
Hypertension Research

Volume: 48, P: 1911-1918
Co-option and neofunctionalization of stomatal executors for defence against herbivores in Brassicales

The authors identified a transcriptional module, FAMA–WASABI MAKER (WSB), for the development of stomata and idioblast myrosin cells. They propose that the conserved and reduced FAMA–WSB module was co-opted before evolving to induce idioblast development.

Makoto Shirakawa
Tomoki Oguro
Toshiro Ito
ResearchOpen Access24 Feb 2025
Nature Plants

Volume: 11, P: 483-504
CD9P-1 expression correlates with the metastatic status of lung cancer, and a truncated form of CD9P-1, GS-168AT2, inhibits in vivo tumour growth

W Guilmain
S Colin
S Al-Mahmood
ResearchOpen Access04 Jan 2011
British Journal of Cancer

Volume: 104, P: 496-504
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers

Y Hirata
N Ogasawara
T Joh
ResearchOpen Access31 Mar 2009
British Journal of Cancer

Volume: 100, P: 1320-1329
Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D

Motomichi Matsuzaki
Osami Misumi
Tsuneyoshi Kuroiwa
ResearchOpen Access08 Apr 2004
Nature

Volume: 428, P: 653-657
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations

Using biobank data from over 250,000 participants, the authors present a detailed picture of regional and individual variation in the tripartite ancestral structure of modern Japanese populations and demonstrate its impact on elevated body mass index.

Kenichi Yamamoto
Shinichi Namba
Yukinori Okada
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-15
Predictive accuracy of partial coherence interferometry and swept-source optical coherence tomography for intraocular lens power calculation

Woong-Joo Whang
Young-Sik Yoo
Choun-Ki Joo
ResearchOpen Access13 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Genome-wide analysis in 212,453 Japanese individuals identifies loci associated with 42 diseases. Comparative analysis with European populations identifies East Asian–specific associations.

Kazuyoshi Ishigaki
Masato Akiyama
Yoichiro Kamatani
Research08 Jun 2020
Nature Genetics

Volume: 52, P: 669-679
A cross-population atlas of genetic associations for 220 human phenotypes

Genome-wide analyses in BioBank Japan, UK Biobank and FinnGen identify ~5,000 new loci associated with 220 human traits. Statistical decomposition of matrices of phenome-wide summary statistics further highlights variants underpinning diseases across populations.

Saori Sakaue
Masahiro Kanai
Yukinori Okada
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1415-1424
High level of Nm23-H1 gene expression is associated with local colorectal cancer progression not with metastases

ZS Zeng
S Hsu
JG Guillem
Research01 Nov 1994
British Journal of Cancer

Volume: 70, P: 1025-1030
Phase I trial and tumour localisation of the anti-EGFR monoclonal antibody ICR62 in head and neck or lung cancer

H Modjtahedi
T Hickish
M Gore
Research01 Jan 1996
British Journal of Cancer

Volume: 73, P: 228-235
Heparin-binding EGF-like growth factor is an early response gene to chemotherapy and contributes to chemotherapy resistance

F Wang
R Liu
J C Cusack
Research25 Sept 2006
Oncogene

Volume: 26, P: 2006-2016
Expression of NM23 in human melanoma progression and metastasis

DJ Easty
K Maung
DC Bennett
Research01 Jul 1996
British Journal of Cancer

Volume: 74, P: 109-114
The impact of gravity on perceived object height

Björn Jörges
Nils Bury
Laurence R. Harris
ResearchOpen Access04 Oct 2024
npj Microgravity

Volume: 10, P: 1-9
Genetic analysis of right heart structure and function in 40,000 people

Genome-wide analyses of cardiac magnetic resonance imaging data identify loci associated with right heart structure and function. A polygenic predictor of right ventricular ejection fraction is associated with dilated cardiomyopathy risk.

James P. Pirruccello
Paolo Di Achille
Patrick T. Ellinor
Research13 Jun 2022
Nature Genetics

Volume: 54, P: 792-803
Blue organic light-emitting diode with a turn-on voltage of 1.47 V

The requirement of a high applied voltage remains a critical issue for blue organic-light emitting diodes. Here, the authors determine the appropriate donor-acceptor combination for triplet-triplet annihilation upconversion emission, achieving a low turn-on voltage of 1.47 V in blue devices.

Seiichiro Izawa
Masahiro Morimoto
Masahiro Hiramoto
ResearchOpen Access20 Sept 2023
Nature Communications

Volume: 14, P: 1-10
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

The burden of mosaic chromosomal alterations in blood-derived DNA, a type of clonal hematopoiesis, is associated with an increased risk for diverse types of infections, including sepsis and pneumonia.

Seyedeh M. Zekavat
Shu-Hong Lin
Pradeep Natarajan
Research07 Jun 2021
Nature Medicine

Volume: 27, P: 1012-1024
Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

Finding causal variants and genes from GWAS loci results remains a challenge. Here, the authors train a model to predict if a variant affects nearby gene expression, and apply the method to identify new possible causal eQTLs and mechanisms of GWAS loci.

Qingbo S. Wang
David R. Kelley
Hilary K. Finucane
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-11
The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP₃ pathway

Yutaka Takeo
Nobuhiro Kurabayashi
Kamon Sanada
ResearchOpen Access04 May 2016
Scientific Reports

Volume: 6, P: 1-12
Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum

GABAergic neuron progenitors in the cerebellum give rise to Purkinje cells and GABAergic interneurons. Here the authors show that the transcription factors Olig2 and Gsx1 regulate an identity transition from Purkinje cell progenitors to interneuron progenitors during mouse development.

Yusuke Seto
Tomoya Nakatani
Mikio Hoshino
Research18 Feb 2014
Nature Communications

Volume: 5, P: 1-13
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
Downregulation of intracellular nm23-H1 prevents cisplatin-induced DNA damage in oesophageal cancer cells: possible association with Na⁺, K⁺-ATPase

N lizuka
K Miyamoto
M Oka
ResearchOpen Access10 Oct 2000
British Journal of Cancer

Volume: 83, P: 1209-1215
The nm23-H1 gene as a predictor of sensitivity to chemotherapeutic agents in oesophageal squamous cell carcinoma

N Iizuka
K Hirose
M Oka
ResearchOpen Access10 Sept 1999
British Journal of Cancer

Volume: 81, P: 469-475
Contribution of host-derived growth factors to in vivo growth of a transplantable murine mammary carcinoma

DE Davies
S Farmer
P Alexander
Research01 Aug 1994
British Journal of Cancer

Volume: 70, P: 263-269
Epidermal growth factor receptor expression by human squamous cell carcinomas of the head and neck, cell lines and xenografts

P Stanton
S Richards
BW Ozanne
Research01 Sept 1994
British Journal of Cancer

Volume: 70, P: 427-433
c-erbB-4 protein expression in human breast cancer

T Y Kew
J A Bell
I O Ellis
ResearchOpen Access22 Feb 2000
British Journal of Cancer

Volume: 82, P: 1163-1170
Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase

Klaus Elenius
Caroline J Choi
Michael Klagsbrun
Research27 Apr 1999
Oncogene

Volume: 18, P: 2607-2615
Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

Wnt proteins mediate embryonic development but how protein localization and patterning is regulated is unclear. Here, the authors show that distinct structures with different heparan sulfate modifications (‘N-sulfo-rich’ and ‘N-acetyl-rich’) regulate cellular localization and signal transduction of Wnt8 in Xenopus.

Yusuke Mii
Takayoshi Yamamoto
Masanori Taira
ResearchOpen Access07 Dec 2017
Nature Communications

Volume: 8, P: 1-19
Experimental observation of ferrielectricity in multiferroic DyMn₂O₅

Z. Y. Zhao
M. F. Liu
J. -M. Liu
ResearchOpen Access05 Feb 2014
Scientific Reports

Volume: 4, P: 1-7
GENERATIVE CELL SPECIFIC 1 is essential for angiosperm fertilization

Toshiyuki Mori
Haruko Kuroiwa
Tsuneyoshi Kuroiwa
Research25 Dec 2005
Nature Cell Biology

Volume: 8, P: 64-71
Reorganization of the ancestral sex-determining regions during the evolution of trioecy in Pleodorina starrii

Whole genome sequencing data reveals three distinct sex phenotypes derived from ancestral sex chromosome reorganization in a green algae species.

Kohei Takahashi
Shigekatsu Suzuki
Hisayoshi Nozaki
ResearchOpen Access09 Jun 2023
Communications Biology

Volume: 6, P: 1-10
The Association between Morning Hypertension and Metabolic Syndrome in Hypertensive Patients

Shinji Tamaki
Yasuyuki Nakamura
Minoru Horie
Research01 Oct 2006
Hypertension Research

Volume: 29, P: 783-788
Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in a General Sample: The Shigaraki Study

Shinji Tamaki
Yasuyuki Nakamura
Hirotsugu Ueshima
Research01 Nov 2006
Hypertension Research

Volume: 29, P: 891-896
Combined Analysis of Polymorphisms in Angiotensinogen and Adducin Genes and Their Effects on Hypertension in a Japanese Sample: The Shigaraki Study

Shinji Tamaki
Yasuyuki Nakamura
Hirotsugu Ueshima
Research01 Aug 2005
Hypertension Research

Volume: 28, P: 645-650
Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma

Y Ito
T Takeda
N Matsuura
ResearchOpen Access15 May 2001
British Journal of Cancer

Volume: 84, P: 1377-1383
TATI (tumour-associated trypsin inhibitor) as a marker of ovarian cancer

M Medl
E Ogris
S Leodolter
Research01 May 1995
British Journal of Cancer

Volume: 71, P: 1051-1054
Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck

P Mhawech
P Dulguerov
A S Allal
ResearchOpen Access20 Jan 2004
British Journal of Cancer

Volume: 90, P: 471-475
A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population

Noriko Ohyama
Masatoshi Matsunami
Shiro Maeda
ResearchOpen Access22 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα₁₃/RhoA axis in B cells

M O'Hayre
A Inoue
J S Gutkind
Research30 Nov 2015
Oncogene

Volume: 35, P: 3771-3780
Osteopontin is a marker for cancer aggressiveness and patient survival

G F Weber
G S Lett
N C Haubein
ResearchOpen Access07 Sept 2010
British Journal of Cancer

Volume: 103, P: 861-869
Expression level of integrin α5 on tumour cells affects the rate of metastasis to the kidney

N Tani
S Higashiyama
N Matsuura
ResearchOpen Access28 Jan 2003
British Journal of Cancer

Volume: 88, P: 327-333
Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression

K Shiraishi
K Yamasaki
S Higashiyama
Research24 Jul 2006
Oncogene

Volume: 26, P: 339-348
TP53 mutational pattern in Spanish and Polish non-small cell lung cancer patients: null mutations are associated with poor prognosis

Josep Maria de Anta
Ewa Jassem
Montserrat Sánchez-Céspedes
Research11 Dec 1997
Oncogene

Volume: 15, P: 2951-2958

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