Amide bond formation is essential in both organic and medicinal chemistry; however, most existing methods present poor ecological efficiency. Here, the authors present a scalable and sustainable methodology for synthesizing N-substituted amides from nitroarenes, nitroalkenes, nitroalkyls, and acyl saccharin in aqueous media, demonstrating applicability in the synthesis of pharmaceuticals and agrochemicals, especially an effective multigram-scale synthesis of paracetamol, and solvent recycling.
- Sunil L. Khamkar
- Rayala Mohan
- D. Srinivasa Reddy
