Search

This study presents a clinical-grade autonomous pipeline combining high-resolution whole-slide tomography, edge computing and artificial intelligence, achieving high accuracy in cervical cytology and enabling scalable and objective diagnostics.

Metal–sulfur motifs are commonly found in enzymatic active sites and heterogeneous catalysis, but they remain underexplored in porous solids. Now, sulfur-based ligands have been incorporated into metal–organic frameworks through post-synthetic modifications. The resulting sulfide MOFs exhibit enhanced catalytic performance in the selective hydrogenation of nitroarenes compared with their parent MOFs containing terminal or bridging chloride and hydroxyl groups.

Direct air capture is a promising technology to mitigate the rising atmospheric CO₂ concentrations contributing to climate change. Here a covalent organic framework with high CO₂ capacity and cycling stability is reported to be capable of selectively and rapidly removing CO₂ from open air.

Cement production is one of the largest industrial sources of global CO2 emissions. This study presents an electrochemical process that recycles waste cement into hydrated lime for cement production, eliminating the need for limestone and reducing CO2 emissions by 99.8%

Crystal growth is visualized inside non-transparent liquid metals, while preserving their original state, using X-ray micro-computed tomography to reveal how liquid metal solvent composition and cooling conditions influence crystal formation.

Anion-exchange membrane water electrolysers have the potential to rival more costly acidic proton-exchange membrane electrolysers, but their performance and efficiency commonly still fall short. Now an anion-exchange membrane water electrolyser is prepared with a NiFe layered double hydroxide catalyst-coated membrane that achieves high current densities above 2 A cm⁻² at 1.8 V and operando X-ray absorption spectroscopy is used to track the formation of the catalytically active γ-LDH phase.

Lactic acid is a platform chemical with a variety of applications that is produced and used on a large scale. Here, the authors convert glycerol—a by-product of biodiesel production—into lactic acid in a highly efficient, homogenous catalytic process.

Electrolysis of dirty water is an attractive route to clean hydrogen, but fluctuating surface pH quickly ruins electrodes. Here, the authors report an ion-selective polymer gate that steadies surface pH, bars harmful ions and lets seawater-fed cells run 1500 h with pure-water durability.

Activated cotton textiles are promising for wearable energy storage due to their flexibility and high conductivity, but scalability is an issue. Here, the authors combine supercapacitors and solar cells on activated cotton textiles via scalable roll-to-roll assembly to make self-sustaining power packs.

Nickel hydroxide is a promising material for capacitor electrodes and most research has focussed on the crystalline form. Here, the authors report that amorphous nickel hydroxide nanospheres, which may be synthesized relatively easily, also exhibit excellent integrated electrochemical performance.

A RuNi/NC catalyst with optimized interfacial water dynamics for alkaline H₂ evolution is reported. The designed strategy shows enhanced catalytic activity by achieving 12 mV overpotential at 10 mA cm^‒2 and 13.6-fold higher mass activity than Pt/C.

A cortical premotor network in HVC, once initiated, can sustain and regulate the sequential production of zebra finch song syllables without major extrinsic inputs.

The authors show that protein TFG self-organizes to form a hollow sphere that helps to guide and spatially organize bidirectional transport at a critical junction between the ER and Golgi in the early secretory pathway.

CO₂ reduction (CO₂R) to C₂₊ alcohols has low selectivity and current density due to competing C₂+ pathways that produce ethylene. Defect-rich Pr–Cu oxide heterointerfaces are developed to induce asymmetric carbon–carbon coupling and selective hydrodeoxygenation of CO₂R intermediates, accelerating the production of C₂₊ alcohols.

Current catalysts for water-splitting electrolyzers are scarce and unstable under acidic conditions. Here, the authors report that cobalt oxyhydroxide works across all pH levels, delivering stable industrial-scale current for 400 h while its redox behavior adapts with acidity.

Hydroxide exchange membrane fuel cells are promising as an energy conversion technology, but require platinum group metal electrocatalysts for their application. A Ni-based hydrogen oxidation reaction catalyst is now shown to exhibit unprecedented electrochemical performance.

High-entropy nanocarbides (HENCs) containing 5–22 metal elements are synthesized through a nanoconfined impulse synthetic strategy enabled by Joule heating-induced in situ reactions in carbon nanotube films. These HENCs exhibit multi-element effects and enhanced electrocatalytic activities due to their nanoscale size and modified catalytic sites.

Most of the current understanding on electrocatalysis is obtained on bulk catalysts but has not been fully verified on nanostructured materials. An alternative alkaline hydrogen evolution reaction mechanism is proposed here for nanostructured catalysts.

The small molecule Yoda1 is a crucial pharmacological tool for studying the ion channel PIEZO1. Here, Verkest et al. combine 3DMINFLUX nanoscopy, electrophysiology and mutagenesis to obtain unprecedented molecular insights into Yoda’s mode-of-action.

Cells can sense mitochondrial damage through signalling via an unimported mitochondrial targeting sequence.

Electrocatalysts for CO₂ reduction are typically prepared and optimized ex situ before the reaction begins, but during reactions they may undergo changes that lower their performance. Here the authors show that active Cu catalysts can be formed on a recoverable basis and removed in situ during the CO₂ reduction reaction, improving the stability of the system.

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

Macrolide antibiotics halt protein synthesis in a sequence-dependent manner. Here, authors reveal a comprehensive molecular mechanism by which macrolides induce ribosome stalling selectively at Arg/Lys-X-Arg/Lys motifs in growing polypeptide chains.

The authors show that NAT10 is upregulated with T cell antigen receptor signaling and that T cell-specific NAT10 deficiency results in diminished numbers of naive T cells, translating to an inability to mount a significant antiviral T cell response.

DNA double-strand breaks are primarily repaired by non-homologous end joining, which requires synapsis of broken DNA ends. Here, the authors show that DNA end configurations, particularly short microhomologies, dictate synaptic complex formation and can bypass XLF to promote close end joining.

Targeting neurons that regulate energy balance may offer new approaches for obesity treatment. Here, authors show that chemogenetic and pharmacological manipulation of GABAergic neurons in the DRN/vlPAG increases adaptive thermogenesis and reduces weight gain in mice fed a highfat diet.

In plants, H3K4me2 is associated with repressed states of chromatin. Noyori et al. show that H3K4me2 works with H2A.Z and Polycomb repressive marks to gradually shift chromatin into a repressed state.

Reactive capture—integrating CO₂ capture and electrochemical valorization—improves energy efficiency by eliminating gas-phase CO₂ desorption. Here, authors design a redox-active polymeric network to boost the direct conversion of captured CO₂ to multicarbon products with CO₂-free gas product stream.

CDK11 associates with SF3B1 and phosphorylates threonine residues at the N terminus of SF3B1 during spliceosome activation, and the inhibition of CDK11 blocks the activation and leads to widespread intron retention and the accumulation of non-functional spliceosomes on pre-mRNAs and chromatin.

Redox-flow batteries with organic-based electrolytes hold many advantages over conventional-flow batteries. Here the authors report a high-performance flow battery based on alloxazine, an aqueous-stable and soluble redox-active organic molecule resembling the backbone structure of vitamin B2.

Copper-based catalysts are preferred for electrochemical CO₂ reduction to hydrocarbons, which however easily undergo structural reconstruction. Here, the authors report a class of reconstruction-resistant copper sites with tunable electronic structures through σ-π dative bonding interaction.

R-loops formed by RNA hybridization to DNA template strand during transcription influence HIV-1 integration into the CD4⁺ T cell genome. The unwinding of R-loops by splicing helicase Aquarius facilitates integration into speckle-associated domains.

The inability of intrinsically photosensitive retinal ganglion cells to shift the circadian clock in the suprachiasmatic nucleus during daytime is caused by light-dependent depolarization block of these cells.

Hox genes are known to control anteroposterior patterning, including the vertebrate spine. Here Xue et al. show that maternal Smchd1 regulates Hox expression in an epigenetic manner, and that wild type offspring from heterozygous mothers show skeletal homeotic transformations as a result of this dysregulation.

Neural mechanisms underlying motivation-driven behaviors are not fully understood. Here authors show that non-cholinergic neurons in rodent basal forebrain link sensory stimuli with motivational states and experience-driven plasticity.

This study highlights a protocol that converts various perfluoroalkyl and polyfluoroalkyl substances (PFASs), including fluoroplastics, into valuable fluorochemicals through a solvent-free mechanochemical process, thereby enabling fluorine recovery and contributing to a sustainable circular fluorine economy.

Polymeric stabilization of photocatalysts at the gas–liquid interface enhances both the catalytic activity and stability for solar hydrogen production from plastic waste. The photocatalyst retains its performance over 2 months under harsh conditions, and scaling to 1 m² yields a hydrogen production rate of 0.906 l per day from polyethylene terephthalate waste under natural sunlight.

Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.

Charged-sorbents are a new class of designer sorbent materials for the capture of carbon dioxide from the atmosphere, and can be regenerated at low temperatures with direct heating generation using renewable electricity.

Atomically thin alloys are promising electrocatalysts but suffer from poor homogeneity. Here a multi-element metallene system is synthesized using an auto-catalytic method. The hexagonal close-packed intermetallic structure and isolated surface Ru–O₃ sites provide optimal adsorption of intermediates, contributing to high hydrogen oxidation activity and stability.

Urea oxidation could be a lower-energy alternative to water oxidation in hydrogen-producing electrolysers, but improved catalysts are required to facilitate the reaction. Geng et al. report nickel ferrocyanide as a promising catalyst and suggest that it operates via a different pathway to that of previous materials.

Designing synthetic systems to convert light into fuel is crucial in renewable energy development. Here, authors study electrodissolution in nickel thin films from metal-insulator-semiconductor junctions and find decreased homogeneity to improve junction properties and catalytic performances.

The sluggish kinetics of the oxygen evolution reaction (OER) is the main obstacle in water splitting which is generally catalyzed by precious metals. Here, authors report a DFT predicted non-precious bimetallic phosphate electrocatalyst that displays high OER activity and stability.

Understanding the mechanisms underlying the survival of drug tolerant persister cells following chemotherapy remains elusive. Here, multi-omics analysis and experimental approaches show that the germ-cell-specific H3K4 methyltransferase PRDM9 promotes metabolic rewiring in glioblastoma stem cells.

Cleaner hydrogen production can help energy sustainability. The use of yeast biomass-derived materials to develop efficient, eco-friendly and economical catalysts—compared with industrially adopted catalysts—is shown to improve hydrogen production as a strategy towards a sustainable energy system.