Follicular helper T (TFH) cells provide survival and selection signals to germinal center B cells. Here, Carola Vinuesa and colleagues describe a regulatory T cell subset that co-opts the differentiation program of TFH cells and limits their numbers in vivo. Ablation of these TFH-like, T regulatory cells alters the number of antigen-specific B cells suggesting regulatory T cells modulate germinal center responses.
- Michelle A Linterman
- Wim Pierson
- Carola G Vinuesa
