Nature Search

Mitochondrial complex I activity in microglia sustains neuroinflammation

Blocking mitochondrial complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in vivo in an animal disease model.

L. Peruzzotti-Jametti
C. M. Willis
S. Pluchino
ResearchOpen Access13 Mar 2024
Nature

Volume: 628, P: 195-203
Towards subtypes — deep endometriosis oestrogen receptor-α expression

Most research treats endometriosis as a single entity, potentially obscuring informative subtype-specific associations with risk factors, biomarkers and treatment responses. A 2020 study raises the hypothesis that deep endometriosis oestrogen receptor-α expression might be associated with progestin treatment and the degree of post-surgical excision pain.

Amy L. Shafrir
Stacey A. Missmer
News & Views16 Jul 2020
Nature Reviews Endocrinology

Volume: 16, P: 541-542
The therapeutic potential of neural stem cells

Transplantation of neural stem cells holds great promise for treating neurological disorders. Martino and Pluchino argue that neural stem cells achieve their therapeutic efficacy exculsively by a cell-replacement mechanism, rather than by the recently proposed alternative mechanism of bystander neuroprotection.

Gianvito Martino
Stefano Pluchino
Reviews01 May 2006
Nature Reviews Neuroscience

Volume: 7, P: 395-406
Extracellular vesicles are independent metabolic units with asparaginase activity

Metabolomics analysis of neural stem/progenitor cell-derived extracellular vesicles reveals asparaginase activity catalyzed by L-asparaginase-like protein 1.

Nunzio Iraci
Edoardo Gaude
Stefano Pluchino
Research03 Jul 2017
Nature Chemical Biology

Volume: 13, P: 951-955
Dissecting the human leptomeninges at single-cell resolution

The meninges protect the central nervous system at the brain border, and its dysfunction can lead to neural inflammation and cell damage. Here, the authors uncover the gene signatures of diverse cell types in the aged human leptomeninges and highlight their changes in Alzheimer’s Disease.

Nicola A. Kearns
Artemis Iatrou
Yanling Wang
ResearchOpen Access03 Nov 2023
Nature Communications

Volume: 14, P: 1-16
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

A key challenge is to find/re-purpose approved drugs that could be used in humans to induce autophagy-associated clearance of neurodegenerative proteins. Here, authors demonstrate that felodipine, an anti-hypertensive drug, can induce autophagy and clear a variety of aggregated neurodegenerative disease-associated proteins in mouse brains at plasma concentrations similar to those that would be seen in humans taking the drug.

Farah H. Siddiqi
Fiona M. Menzies
David C. Rubinsztein
ResearchOpen Access18 Apr 2019
Nature Communications

Volume: 10, P: 1-14
Genetic remodeling of soil diazotrophs enables partial replacement of synthetic nitrogen fertilizer with biological nitrogen fixation in maize

Rafael Martinez-Feria
Maegen B. Simmonds
Karsten Temme
ResearchOpen Access12 Nov 2024
Scientific Reports

Volume: 14, P: 1-18
Resistance to osimertinib in advanced EGFR-mutated NSCLC: a prospective study of molecular genotyping on tissue and liquid biopsies

A. Leonetti
M. Verzè
M. Tiseo
Research08 Nov 2023
British Journal of Cancer

Volume: 130, P: 135-142
Evidence for a Role of Progesterone in Menstrual Cycle-Related Variability in Prepulse Inhibition in Healthy Young Women

Veena Kumari
Joanna Konstantinou
Anthony J Cleare
Research02 Dec 2009
Neuropsychopharmacology

Volume: 35, P: 929-937
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, enables expanded Tregs to convert ATP to immunosuppressive adenosine. Given this, the data suggests that Treg expansion protocols should be optimised for CD39/CD73 co-expression to enhance therapeutic potential.

Lorna B. Jarvis
Daniel B. Rainbow
Joanne L. Jones
ResearchOpen Access14 Oct 2021
Communications Biology

Volume: 4, P: 1-14
IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis

E Butti
A Bergami
R Furlan
Research31 Jan 2008
Gene Therapy

Volume: 15, P: 504-515

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Mitochondrial complex I activity in microglia sustains neuroinflammation

Towards subtypes — deep endometriosis oestrogen receptor-α expression

The therapeutic potential of neural stem cells

Extracellular vesicles are independent metabolic units with asparaginase activity

Dissecting the human leptomeninges at single-cell resolution

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

Genetic remodeling of soil diazotrophs enables partial replacement of synthetic nitrogen fertilizer with biological nitrogen fixation in maize

Resistance to osimertinib in advanced EGFR-mutated NSCLC: a prospective study of molecular genotyping on tissue and liquid biopsies

Evidence for a Role of Progesterone in Menstrual Cycle-Related Variability in Prepulse Inhibition in Healthy Young Women

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis

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