Wnt signaling is thought to have an important role in the development of several human cancers, but its role in renal cell carcinoma (RCC) seems to be distinct from other cancer types. In this Review, the authors describe our current understanding of Wnt signaling and the action of several endogenous Wnt antagonists in the context of RCC, and discuss how study of these proteins might lead to the development of effective new targeted therapies for patients with this malignancy.
- Sharanjot Saini
- Shahana Majid
- Rajvir Dahiya