Neurofibromatosis type 1 (NF1) and type 2 (NF2) are distinct genetic disorders that are characterized by an increased incidence of tumour development, predominantly affecting the nervous system. The authors discuss the clinical features, genetic aetiologies, and pathogenesis of NF1 and NF2, the current treatment options as well as advances in clinical and preclinical research that will impact on the future treatment of these tumours.
- Andrew L. Lin
- David H. Gutmann
