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Showing 1–50 of 52 results

Advanced filters: Author: S Varadarajan Clear advanced filters

Bhopal disaster: India blames Union Carbide

K. S. Jayaraman
News02 Jan 1986
Nature

Volume: 319, P: 7
India's nuclear tests meet with domestic praise and protests

new delhi
Five nuclear tests beginning on Budda's birthday in the land of Mahatma Gandhi have blasted a large hole in India's image as a spiritual, non violent nation.

K. S. Jayaraman
News21 May 1998
Nature

Volume: 393, P: 197-198
Indian science: All change at the top

K.S. Jayaraman
News20 Feb 1986
Nature

Volume: 319, P: 612
A Curious Atmospheric Phenomenon

A. S. E. ACKERMANN
Research01 Sept 1938
Nature

Volume: 142, P: 482-483
Vernalization of Excised Embryos

F. G. GREGORY
R. S. DE ROPP
Research01 Sept 1938
Nature

Volume: 142, P: 481-482
Indian technology: Quest for self-reliance runs into trouble

K.S. Jayaraman
News14 Nov 1985
Nature

Volume: 318, P: 93
Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers

We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion, intratumoural survival and antitumour activity of GPC3 (expressed in a group of solid cancers) CAR T cells.

David Steffin
Nisha Ghatwai
Andras Heczey
Research27 Nov 2024
Nature

Volume: 637, P: 940-946
Author Correction: A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

Christopher L. Yankaskas
Keyata N. Thompson
Konstantinos Konstantopoulos
Amendments and Corrections05 Feb 2025
Nature Biomedical Engineering

Volume: 9, P: 285
A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases

Using more than 300 serum samples from individuals with an age range of 1-88 years old, the authors here show that older adults possess higher breadth of antibody reactivity to avian influenza virus (AIV) neuraminidases, potentially explaining the age-specific risks of AIV human infections.

Zaolan Liang
Xia Lin
Sook-San Wong
ResearchOpen Access03 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Author Correction: Detection of anaemia from retinal fundus images via deep learning

Akinori Mitani
Abigail Huang
Avinash V. Varadarajan
Amendments and Corrections12 Feb 2020
Nature Biomedical Engineering

Volume: 4, P: 242
Predicting optical coherence tomography-derived diabetic macular edema grades from fundus photographs using deep learning

Diabetic eye disease is a cause of preventable blindness and accurate and timely referral of patients with diabetic macular edema is important to start treatment. Here the authors present a deep learning model that can predict the presence of diabetic macular edema from color fundus photographs with superior specificity and positive predictive value compared to retinal specialists.

Avinash V. Varadarajan
Pinal Bavishi
Dale R. Webster
ResearchOpen Access08 Jan 2020
Nature Communications

Volume: 11, P: 1-8
Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction

Systemic inflammation is recognized as a central pathobiologic feature in heart failure with preserved ejection fraction (HFpEF). Here, the authors report 70 pro- and anti-inflammatory eicosanoid and eicosanoid-related metabolites associated with HFpEF status.

Emily S. Lau
Athar Roshandelpoor
Jennifer E. Ho
ResearchOpen Access20 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Hidden modes of DNA binding by human nuclear receptors

Nuclear receptors (NR) are drug-responsive master regulators. Here, authors map DNA binding profiles of all human NRs. Their MinSeq Find algorithm identifies masked NR binding sites in genomes and maps ~10% of orphan SNPs linked to numerous diseases.

Devesh Bhimsaria
José A. Rodríguez-Martínez
Aseem Z. Ansari
ResearchOpen Access13 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning

Deep learning predicts, from retinal images, cardiovascular risk factors—such as smoking status, blood pressure and age—not previously thought to be present or quantifiable in these images.

Ryan Poplin
Avinash V. Varadarajan
Dale R. Webster
Research19 Feb 2018
Nature Biomedical Engineering

Volume: 2, P: 158-164
Detection of anaemia from retinal fundus images via deep learning

Machine-learning algorithms trained with retinal fundus images, with subject metadata or with both data types, predict haemoglobin concentration with mean absolute errors lower than 0.75 g dl^–1 and anaemia with areas under the curve in the range of 0.74–0.89.

Akinori Mitani
Abigail Huang
Avinash V. Varadarajan
Research23 Dec 2019
Nature Biomedical Engineering

Volume: 4, P: 18-27
Author Correction: Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Ali Rezvan
Gabrielle Romain
Navin Varadarajan
Amendments and Corrections22 May 2024
Nature Cancer

Volume: 5, P: 954
Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Rezvan and colleagues profile the infusion product from individuals with DLBCL treated with CAR T cells and integrate functional profiling by timelapse imaging microscopy and scRNA-seq to identify a signature of migratory CD8⁺ T cells associated with response.

Ali Rezvan
Gabrielle Romain
Navin Varadarajan
Research15 May 2024
Nature Cancer

Volume: 5, P: 1010-1023
Author Correction: KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

Ye Li
Rafet Basar
Katayoun Rezvani
Amendments and Corrections05 Jan 2024
Nature Medicine

Volume: 30, P: 906
Atomic power struggle under way in India

K. S. Jayaraman
News18 Feb 1987
Nature

Volume: 325, P: 565
Detection of signs of disease in external photographs of the eyes via deep learning

Deep-learning models trained on external eye photographs can detect diabetic retinopathy, diabetic macular oedema and poor blood glucose control more accurately than models relying on demographic and medical history data.

Boris Babenko
Akinori Mitani
Yun Liu
Research29 Mar 2022
Nature Biomedical Engineering

Volume: 6, P: 1370-1383
India's research council to undergo belated modernization

K. S. Jayaraman
News01 Mar 1987
Nature

Volume: 326, P: 120
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

A redesigned antiviral miniprotein based on a dimeric helix-hairpin motif binds and dimerizes the RBD of the SARS-CoV-2 spike protein and inhibits viral infection by inhibiting spike interaction with ACE2.

Bhavesh Khatri
Ishika Pramanick
Jayanta Chatterjee
ResearchOpen Access02 Jun 2022
Nature Chemical Biology

Volume: 18, P: 1046-1055
KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

A new dual-chimeric antigen receptor (CAR) system enhances the antitumor activity of CAR natural killer cells and makes them less susceptible to therapeutic resistance in preclinical models.

Ye Li
Rafet Basar
Katayoun Rezvani
Research29 Sept 2022
Nature Medicine

Volume: 28, P: 2133-2144
India opts for self-control

K. S. Jayaraman
News22 Feb 1990
Nature

Volume: 343, P: 680
Bhopal disaster: Technical inquiry under way

K.S. Jayaraman
News10 Jan 1985
Nature

Volume: 313, P: 89
A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

A microfluidic assay predicts the metastatic potential of breast cancer specimens by quantifying the abundance and proliferative index of the migratory cells within them.

Christopher L. Yankaskas
Keyata N. Thompson
Konstantinos Konstantopoulos
Research06 May 2019
Nature Biomedical Engineering

Volume: 3, P: 452-465
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

IDH1- and IDH2-mutant cancer cells aberrantly accumulate D2-hydroxyglutarate (D2-HG). Here, Lin et al. find loss-of-function mutations in D2-hydroxyglutarate dehydrogenase (D2HGDH), which converts D2-HG to alpha-ketoglutarate (α-KG), in diffuse large B-cell lymphomas and show that D2HGDH via α-KG regulates the expression and activity of IDH2.

An-Ping Lin
Saman Abbas
Ricardo C. T. Aguiar
ResearchOpen Access16 Jul 2015
Nature Communications

Volume: 6, P: 1-14
HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

Oral vaccination is a potential option to elicit systemic and mucosal immunity against HIV. Here, Jones et al. show that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is superior to topical application of vaccines to oral tissues.

Andrew T. Jones
Xiaoying Shen
Rama Rao Amara
ResearchOpen Access18 Feb 2019
Nature Communications

Volume: 10, P: 1-14
AAV gene therapy for hereditary spastic paraplegia type 50: a phase 1 trial in a single patient

In a phase 1 trial in a single patient with hereditary spastic paraplegia type 50, a personalized AAV9-based gene therapy was developed within 3 years from diagnosis and was well tolerated, showing preliminary evidence of disease stabilization.

James J. Dowling
Terry Pirovolakis
Steven J. Gray
ResearchOpen Access28 Jun 2024
Nature Medicine

Volume: 30, P: 1882-1887
ERABiLNet: enhanced residual attention with bidirectional long short-term memory

Koteeswaran Seerangan
Malarvizhi Nandagopal
Shitharth Selvarajan
ResearchOpen Access04 Sept 2024
Scientific Reports

Volume: 14, P: 1-33
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features

Whole-genome sequencing of chronic lymphocytic leukemia from 485 patients identifies putative coding and noncoding drivers of disease. Genomically defined subgroups show distinct clinical and biological characteristics.

Pauline Robbe
Kate E. Ridout
Anna Schuh
ResearchOpen Access04 Nov 2022
Nature Genetics

Volume: 54, P: 1675-1689
Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

David Estoppey
Jeffrey W. Hewett
Dominic Hoepfner
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-6
Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults

Athena P. Y. Li
Carolyn A. Cohen
Sophie A. Valkenburg
ResearchOpen Access16 Feb 2021
npj Vaccines

Volume: 6, P: 1-12
Loading-rate-independent delay of catastrophic avalanches in a bulk metallic glass

S. H. Chen
K. C. Chan
P. K. Liaw
ResearchOpen Access25 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
Estimating best nanomaterial for energy harvesting through reinforcement learning DQN coupled with fuzzy PROMETHEE under road-based conditions

Sekar Kidambi Raju
Ganesh Karthikeyan Varadarajan
S. K. Towfek
ResearchOpen Access14 Oct 2024
Scientific Reports

Volume: 14, P: 1-23
An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1

Adithi R. Varadarajan
Raymond N. Allan
Christian H. Ahrens
ResearchOpen Access30 Oct 2020
npj Biofilms and Microbiomes

Volume: 6, P: 1-17
Tumor biomechanical stiffness by magnetic resonance elastography predicts surgical outcomes and identifies biomarkers in vestibular schwannoma and meningioma

Bailey H. Duhon
Kristin Thompson
Yin Ren
ResearchOpen Access24 Jun 2024
Scientific Reports

Volume: 14, P: 1-13
Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants

Nidhi Mittal
Sahil Kumar
Raghavan Varadarajan
ResearchOpen Access25 Oct 2023
npj Vaccines

Volume: 8, P: 1-15
Scalable mapping of myelin and neuron density in the human brain with micrometer resolution

Shuaibin Chang
Divya Varadarajan
Hui Wang
ResearchOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1-11
Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome

Patrick Lao
Natalie Edwards
Adam M. Brickman
ResearchOpen Access29 May 2024
Scientific Reports

Volume: 14, P: 1-12
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

Ye Wang
Morvarid Mohseni
Silvia Goldoni
ResearchOpen Access14 Jan 2021
Scientific Reports

Volume: 11, P: 1-23
Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon

Manuel Delgado Caceres
Katharina Angerpointner
Denitsa Docheva
ResearchOpen Access05 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-13
High-throughput, Label-Free Quantitative Proteomic Studies of the Anticancer Effects of Electrical Pulses with Turmeric Silver Nanoparticles: an in vitro Model Study

Lakshya Mittal
Ignacio G. Camarillo
Raji Sundararajan
ResearchOpen Access29 Apr 2020
Scientific Reports

Volume: 10, P: 1-18
CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression

Kristen Fousek
Junji Watanabe
Nabil Ahmed
ResearchOpen Access24 Mar 2020
Leukemia

Volume: 35, P: 75-89
Machine learning for technical skill assessment in surgery: a systematic review

Kyle Lam
Junhong Chen
James M. Kinross
ReviewsOpen Access03 Mar 2022
npj Digital Medicine

Volume: 5, P: 1-16
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1

J K Son
S Varadarajan
S B Bratton
Research19 Feb 2010
Cell Death & Differentiation

Volume: 17, P: 1288-1301
High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-X_L in chronic myeloid leukemia

C M Lucas
M Milani
S Varadarajan
ResearchOpen Access29 Feb 2016
Leukemia

Volume: 30, P: 1273-1281
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum

S Varadarajan
E T W Bampton
G M Cohen
Research07 Sept 2012
Cell Death & Differentiation

Volume: 19, P: 1896-1907
The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration

S Varadarajan
C Breda
G M Cohen
Research06 Feb 2015
Cell Death & Differentiation

Volume: 22, P: 1388-1396

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