Structural features of DNA double-strand break (DSB) ends play key roles in determining DNA repair pathway usage and outcomes. Here, the authors identify ERCC6L2, a poorly characterized ATPase, as playing a minimal role in blunt end DSB repair but crucial for repair of staggered end DSBs.
- Eric J. Aird
- Almudena Serrano-Benitez
- Stephen P. Jackson
