Some bacteria interact with the endoplasmic reticulum (ER) to generate intracellular compartments that promote bacterial replication. However, conditions of physiological stress in the ER elicit the unfolded protein response (UPR), which is a cytoprotective response that is also involved in innate immune sensing. Here, Celli and Tsolis discuss how bacteria and the ER interact, including how bacteria induce the UPR, how subversion of the UPR promotes bacterial proliferation and how the UPR participates in innate immune responses against intracellular bacteria.
- Jean Celli
- Renée M. Tsolis
