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Showing 1–3 of 3 results
Advanced filters: Author: S. Nitayaphan Clear advanced filters

  • Here, using longitudinal pre- and post-infection samples from the RV217 Early Capture HIV Cohort Study, the authors show that mucosa-associated invariant T (MAIT) cells become activated and expand during the early acute phase of HIV infection, with subsequent reprogramming towards innate-like functionality.

    • Kerri G. Lal
    • Dohoon Kim
    • Johan K. Sandberg
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The RV144 vaccine trial showed reduced risk of HIV-1 acquisition, but mechanisms underlying protection are poorly understood. Here, Fourati et al. assess the transcriptomic profile of blood collected from 223 vaccinees and 40 placebo recipients and identify IRF7 as a mediator of protection.

    • Slim Fourati
    • Susan Pereira Ribeiro
    • Rafick-Pierre Sékaly
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Genetic analysis of breakthrough infections in people vaccinated against HIV-1 show that vaccine efficacy increased by up to 80% against viruses carrying two mutations in Env V2, but also raises the possibility of population-level adaptation to the vaccine.

    • Morgane Rolland
    • Paul T. Edlefsen
    • Jerome H. Kim
    Research
    Nature
    Volume: 490, P: 417-420