BPH–LUTS and erectile dysfunction commonly coexist, and both respond to phosphodiesterase 5 inhibitors. In the opinion of Cellek et al., the underlying pathology of both conditions can be explained by microvascular dysfunction, a vicious cycle of hypoxia, vasoconstriction, altered smooth muscle contractility, and degeneration of autonomic neurons and ganglia.
- Selim Cellek
- Norman E. Cameron
- Dapo Ilo
