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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

S.-W. Grace Cheng
Kelvin P. Davies
Ganjam V. Kalpana
Research01 May 1999
Nature Genetics

Volume: 22, P: 102-105
MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation

Mutations in the transcription factor MEF2B are found in diffuse large B-cell lymphoma. In this study, the authors map the DNA-binding sites of the transcription factor in cells in vitroand find that the mutations decrease the ability of MEF2B to activate transcription.

Julia R. Pon
Jackson Wong
Marco A. Marra
ResearchOpen Access06 Aug 2015
Nature Communications

Volume: 6, P: 1-15
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

Suet Yi Leung, Mao Mao and colleagues report whole-genome sequencing of 100 gastric cancers and DNA copy number, gene expression and methylation profiling of these tumors. They identify new recurrently mutated genes and find mutation of RHOA in 14% of diffuse-type gastric cancers.

Kai Wang
Siu Tsan Yuen
Suet Yi Leung
Research11 May 2014
Nature Genetics

Volume: 46, P: 573-582
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events and discover an effect on conjoined gene transcription.

Tyler Funnell
Shinya Tasaki
Samuel Aparicio
ResearchOpen Access23 Feb 2017
Nature Communications

Volume: 8, P: 1-16
The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Primary triple-negative breast cancers are shown to vary widely and continuously in the degree of clonal evolution and mutational content at the time of diagnosis, with implications for future studies of the disease.

Sohrab P. Shah
Andrew Roth
Samuel Aparicio
Research04 Apr 2012
Nature

Volume: 486, P: 395-399
Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

Sarah E. Dixon-Clarke
Jonathan M. Elkins
Alex N. Bullock
ResearchOpen Access24 Nov 2015
Scientific Reports

Volume: 5, P: 1-13

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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

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