Nature Search

Make Humanity Great Again!

Take back control.

Ian Stewart
Comments & Opinion14 Jul 2021
Nature
Transfer of Biologically Fixed Nitrogen in a Sand Dune Slack Region

W. D. P. STEWART
Research06 May 1967
Nature

Volume: 214, P: 603-604
Scanning immunoelectron microscopy of mouse B and T lymphocytes

D. SCOTT LINTHICUM
STEWART SELL
PARK TREFTS
Research08 Nov 1974
Nature

Volume: 252, P: 173-175
Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders

Stewart Sell
Ralph Buttyan
Ian Guest
ResearchOpen Access27 Jun 2011
Nature Precedings

P: 1
Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates

Radiation and steroid dosing can affect the immune composition of brain metastasis (BM). The authors have designed a pilot study of pre-operative stereotactic radiosurgery with low or high dose of peri-operative dexamethasone for resectable brain metastases, here reporting clinical outcomes and characterization of intratumor TCF1+ CD8+ stem-like T cell immune niches in the brain.

Caroline S. Jansen
Meghana S. Pagadala
Zachary S. Buchwald
ResearchOpen Access14 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms

Joint likelihood mapping across six autoimmune diseases identifies shared and distinct association signals and improves fine-mapping resolution at loci with shared effects, yielding insights into the underlying biological mechanisms.

Matthew R. Lincoln
Noah Connally
Chris Cotsapas
Research13 May 2024
Nature Genetics

Volume: 56, P: 838-845
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Materiality and risk in the age of pervasive AI sensors

Sloane and colleagues review emerging new dimensions of risks associated with materiality and AI algorithms run on pervasive sensors.

Mona Sloane
Emanuel Moss
Vijay Janapa Reddi
Reviews20 Mar 2025
Nature Machine Intelligence

Volume: 7, P: 334-345
Hunter-gatherer sea voyages extended to remotest Mediterranean islands

Archaeological discoveries from Malta suggest that humans were present on the Maltese islands from around 8,500 years ago, providing evidence that Mesolithic hunter-gatherers made sea crossings as long as 100 km.

Eleanor M. L. Scerri
James Blinkhorn
Nicholas C. Vella
ResearchOpen Access09 Apr 2025
Nature

Volume: 641, P: 137-143
Experimental Neonatal Syphilis. II. Immunological Responses of Neonatal Rabbits to Intradermal Inoculation with Treponema pallidum (Nichols Strain)

Darlene Gamboa
James N Miller
Stewart Sell
Research01 Oct 1984
Pediatric Research

Volume: 18, P: 972-979
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Wu et al. utilize multiparametric analysis of early-stage human NSCLC to characterize a population of Vδ1 T cells displaying a resident memory and effector memory phenotype, which were associated with ongoing remission.

Yin Wu
Dhruva Biswas
Charles Swanton
ResearchOpen Access30 May 2022
Nature Cancer

Volume: 3, P: 696-709
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Alive and kicking

Lance Stewart
Correspondence01 Jun 2010
Nature Biotechnology

Volume: 28, P: 556
High book prices

PHILIP J. STEWART
Correspondence22 May 1980
Nature

Volume: 285, P: 186
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma

Here the authors functionally characterize hepatocellular carcinoma associated tertiary lymphoid structures (TLS) in patients treated with neoadjuvant immunotherapy and present further evidence for using these TLS as a biomarker of response to therapy.

Daniel H. Shu
Won Jin Ho
Mark Yarchoan
Research25 Oct 2024
Nature Immunology

Volume: 25, P: 2110-2123
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
An atlas of healthy and injured cell states and niches in the human kidney

A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

Blue B. Lake
Rajasree Menon
Sanjay Jain
ResearchOpen Access19 Jul 2023
Nature

Volume: 619, P: 585-594
Prevalence and architecture of de novo mutations in developmental disorders

Whole-exome analysis of individuals with developmental disorders shows that de novo mutations can equally cause loss or altered protein function, but that most mutations causing altered protein function have not yet been described.

Jeremy F. McRae
Stephen Clayton
Matthew E. Hurles
Research25 Jan 2017
Nature

Volume: 542, P: 433-438
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Lessons learned from Ontario wind energy disputes

Ontario, Canada, has seen a number of policy measures introduced since 2009 to increase wind energy production. This Perspective explores the impacts and implications of those policies on wind energy disputes in terms of health, financial benefit, community engagement and the landscape.

Stewart Fast
Warren Mabee
Melody Tomkow
Reviews25 Jan 2016
Nature Energy

Volume: 1, P: 1-7
The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ghorani et al. use a multiomics approach to characterize the effect of tumour mutational burden on the differentiation of CD4 and CD8 T cell subpopulations in non-small cell lung cancer.

Ehsan Ghorani
James L. Reading
Sergio A. Quezada
Research22 May 2020
Nature Cancer

Volume: 1, P: 546-561
Defining the ‘generalist specialist’ niche for Pleistocene Homo sapiens

The success of humans as the last surviving species of the hominin clade may be explained by our ecological plasticity. Roberts and Stewart review evidence for human dispersal 300,000–12,000 years before present and propose that humans thrived via a unique ‘generalist specialist’ ecological niche.

Patrick Roberts
Brian A. Stewart
Reviews30 Jul 2018
Nature Human Behaviour

Volume: 2, P: 542-550
T-bet optimizes CD4 T-cell responses against influenza through CXCR3-dependent lung trafficking but not functional programming

Kunal Dhume
Caroline M. Finn
K. Kai McKinstry
Research05 Jul 2019
Mucosal Immunology

Volume: 12, P: 1220-1230
Book Reviews

Jacqui Stewart
Books & Arts01 Oct 1985
Heredity

Volume: 55, P: 273
The valuation high ground

Holding the valuation high ground allows a biotech company to get the most value from potential partners. Here is how to establish and defend financial valuation.

Jeffrey J Stewart
Ben Bonifant
Comments & Opinion24 Sept 2009
Bioentrepreneur

P: 1-4
A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility

V Damotte
L Guillot-Noel
B Fontaine
Research16 Jan 2014
Genes & Immunity

Volume: 15, P: 126-132
Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens

To evade immune responses in mammalian hosts, many pathogens use complex genetic systems to vary the surface antigens that are recognized by host defences. In this Review, Kirk Deitsch and colleagues highlight how bacterial, protozoan and fungal pathogens from distinct evolutionary lineages have evolved surprisingly similar mechanisms for antigenic variation.

Kirk W. Deitsch
Sheila A. Lukehart
James R. Stringer
Reviews08 Jun 2009
Nature Reviews Microbiology

Volume: 7, P: 493-503
Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT)

Ian C Guest
Stewart Sell
Research01 Jun 2015
Laboratory Investigation

Volume: 95, P: 886-902
Getting it right the first time

The first few decisions bioentrepreneurs make when forming a company can come back to bite them later, but some careful planning can smooth the way for later success.

Barbara M. Johnson
Comments & Opinion23 Oct 2006
Bioentrepreneur

P: 1-4

Search

Make Humanity Great Again!

Transfer of Biologically Fixed Nitrogen in a Sand Dune Slack Region

Scanning immunoelectron microscopy of mouse B and T lymphocytes

Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders

Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Materiality and risk in the age of pervasive AI sensors

Hunter-gatherer sea voyages extended to remotest Mediterranean islands

Experimental Neonatal Syphilis. II. Immunological Responses of Neonatal Rabbits to Intradermal Inoculation with Treponema pallidum (Nichols Strain)

A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Mapping the human genetic architecture of COVID-19

Alive and kicking

High book prices

Whole-genome sequencing reveals host factors underlying critical COVID-19

A second update on mapping the human genetic architecture of COVID-19

Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma

Genetic mechanisms of critical illness in COVID-19

An atlas of healthy and injured cell states and niches in the human kidney

Prevalence and architecture of de novo mutations in developmental disorders

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Lessons learned from Ontario wind energy disputes

The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Defining the ‘generalist specialist’ niche for Pleistocene Homo sapiens

T-bet optimizes CD4 T-cell responses against influenza through CXCR3-dependent lung trafficking but not functional programming

Book Reviews

The valuation high ground

A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility

Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens

Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT)

Getting it right the first time

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