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Showing 1–7 of 7 results
Advanced filters: Author: Sabine Costagliola Clear advanced filters

  • Transient overexpression of the transcription factors NKX2-1 and PAX8 in a murine cell model is shown to direct the differentiation of embryonic stem cells towards a thyroid follicular cell lineage; the resulting three-dimensional thyroid follicles created by subsequent thyrotropin treatment show hallmarks of thyroid function in vitro and rescue thyroid function in vivo when transplanted into athyroid mice, adding to our understanding of the molecular mechanisms underlying thyroid development.

    • Francesco Antonica
    • Dominika Figini Kasprzyk
    • Sabine Costagliola
    Research
    Nature
    Volume: 491, P: 66-71

  • Hypothyroidism is a common condition that cannot always be satisfactorily treated through continued hormone replacement. Here the authors report the generation of transplantable thyroid organoids derived from human embryonic stem cells that can restore plasma thyroid hormone in athyreotic mice.

    • Mírian Romitti
    • Adrien Tourneur
    • Sabine Costagliola
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Glycoprotein hormone receptors show negative cooperativity following a single molecule of agonist binding to each receptor dimer. Here, constitutively active receptors are shown to display less cooperative allosteric regulation, suggesting a direct relationship between conformational changes in the transmembrane domain and allosteric behaviour of the receptor dimers.

    • Maxime Zoenen
    • Eneko Urizar
    • Sabine Costagliola
    Research
    Nature Communications
    Volume: 3, P: 1-9

  • Ovarian hyperstimulation syndrome (OHSS) is a complication of pregnancy caused by an excessive response to follicle-stimulating hormone (FSH). OHSS can arise spontaneously or after exogenous FSH administration duringin vitrofertilization procedures. Novel genetic predictors of OHSS, including mutations and polymorphisms of the FSH receptor, are described in this Viewpoint.

    • Anne Delbaere
    • Guillaume Smits
    • Sabine Costagliola
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 2, P: 590-591

  • G protein-coupled receptors (GPCRs) are key factors in endocrinology; studies of loss-of-function or gain-of-function mutations have contributed to our understanding of the pathophysiology of several diseases. This Review provides an update on the field of GPCR mutations and endocrine diseases and illustrates how GPCR mutations might contribute to our understanding of the diverse facets of GPCRs involved in the field of endocrinology.

    • Gilbert Vassart
    • Sabine Costagliola
    Reviews
    Nature Reviews Endocrinology
    Volume: 7, P: 362-372