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Advanced filters: Author: Sabrina C. Solley Clear advanced filters

A benchmarked, high-efficiency prime editing platform for multiplexed dropout screening

This work establishes a prime editing platform for high-throughput interrogation of small genetic variants (up to tens of thousands) with negative selection phenotypes.

Ann Cirincione
Danny Simpson
Britt Adamson
ResearchOpen Access19 Nov 2024
Nature Methods

Volume: 22, P: 92-101
Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking

Toettcher, McNamara and colleagues use synthetic ‘signal-recording’ gene circuits on mouse gastruloids and find that cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the gastruloid anterior–posterior axis.

Harold M. McNamara
Sabrina C. Solley
Jared E. Toettcher
Research02 Oct 2024
Nature Cell Biology

Volume: 26, P: 1832-1844
Improving prime editing with an endogenous small RNA-binding protein

Genome-scale genetic screens identify the small RNA-binding protein La as a strong mediator of prime editing.

Jun Yan
Paul Oyler-Castrillo
Britt Adamson
ResearchOpen Access03 Apr 2024
Nature

Volume: 628, P: 639-647