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Showing 1–4 of 4 results
Advanced filters: Author: Sabrina I. Giacometti Clear advanced filters

  • Here the authors investigate of the structural basis of substrate recognition and the catalytic mechanism of the mannosyltransferase PimE, which is crucial for the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs) in Mycobacterium tuberculosis.

    • Yaqi Liu
    • Chelsea M. Brown
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase B EmbB involved in mycobacterial cell wall biosynthesis provides insights into the substrate binding and reaction mechanism. Mapping of the ethambutol resistance associated mutations onto the structure suggests the location of the drug binding site.

    • Yong Zi Tan
    • José Rodrigues
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Cryo-electron microscopy structures of the bacterial O-antigen ligase WaaL, combined with genetics, biochemistry and molecular dynamics simulations, provide insight into the mechanism by which WaaL catalyses the biosynthesis of lipopolysaccharide.

    • Khuram U. Ashraf
    • Rie Nygaard
    • Filippo Mancia
    Research
    Nature
    Volume: 604, P: 371-376

  • Structural, functional and in silico analyses of the chloroquine-resistance transporter PfCRT of Plasmodium falciparum suggest that distinct mechanistic features mediate the resistance to chloroquine and piperaquine in drug-resistant parasites.

    • Jonathan Kim
    • Yong Zi Tan
    • Filippo Mancia
    Research
    Nature
    Volume: 576, P: 315-320