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Restoration of visual function by transplantation of optogenetically engineered photoreceptors

A challenge in cell therapy for photoreceptor degeneration is inducing the grafted cells to grow and maintain light sensitive outer segments. Here, the authors use optogenetics to circumvent this problem and restore visual function in blind mice.

Marcela Garita-Hernandez
Maruša Lampič
Jens Duebel
ResearchOpen Access04 Oct 2019
Nature Communications

Volume: 10, P: 1-13
Bankable human iPSC-derived retinal progenitors represent a valuable source of multipotent cells

An in vitro method can expand and bank retinal progenitor cells from hiPSC-derived retinal organoids, representing a potential source of retinal cells for future cell-based therapies or drug discovery models.

Sandy Gozlan
Vivien Batoumeni
Sacha Reichman
ResearchOpen Access21 Jul 2023
Communications Biology

Volume: 6, P: 1-12
Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model

Dynamic full-field optical coherence tomography (D-FFOCT) is used for live cell imaging of primary porcine retinal pigment epithelium (ppRPE) cultures and human induced pluripotent stem cell-derived RPE (hiRPE) cultures, allowing non-invasive realtime access to organelles and cytoskeleton dynamics in RPE cells.

Kassandra Groux
Anna Verschueren
Kate Grieve
ResearchOpen Access10 Jun 2022
Communications Biology

Volume: 5, P: 1-11
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

Retinoblastoma is the most frequent intraocular paediatric malignancy whose molecular basis remains poorly understood. Here, the authors perform multi-omic analysis and identify two subtypes; one in a cone differentiated state and one more aggressive showing cone dedifferentiation and expressing neuronal markers.

Jing Liu
Daniela Ottaviani
François Radvanyi
ResearchOpen Access22 Sept 2021
Nature Communications

Volume: 12, P: 1-20
Dynamic full-field optical coherence tomography module adapted to commercial microscopes allows longitudinal in vitro cell culture study

Dynamic full-field optical coherence tomography coupled to a commercial microscope with a stage top incubator, allows non-invasive, long term, label-free longitudinal imaging of biological specimens.

Tual Monfort
Salvatore Azzollini
Kate Grieve
ResearchOpen Access28 Sept 2023
Communications Biology

Volume: 6, P: 1-17
Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue

Amélie Rodrigues
Amélie Slembrouck-Brec
Olivier Goureau
ResearchOpen Access16 Aug 2022
npj Regenerative Medicine

Volume: 7, P: 1-22
Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

Jules Scholler
Kassandra Groux
Kate Grieve
ResearchOpen Access17 Aug 2020
Light: Science & Applications

Volume: 9, P: 1-9

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Restoration of visual function by transplantation of optogenetically engineered photoreceptors

Bankable human iPSC-derived retinal progenitors represent a valuable source of multipotent cells

Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model

A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

Dynamic full-field optical coherence tomography module adapted to commercial microscopes allows longitudinal in vitro cell culture study

Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue

Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

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Restoration of visual function by transplantation of optogenetically engineered photoreceptors

Bankable human iPSC-derived retinal progenitors represent a valuable source of multipotent cells

Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model

A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

Dynamic full-field optical coherence tomography module adapted to commercial microscopes allows longitudinal in vitro cell culture study

Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue

Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

Search

Quick links