Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. Here we use a bottlebrush prodrug platform to show that the delivery of three drugs in a synergistic combination in animal models outperforms other combinatorial approaches for multiple myeloma therapy.
- Alexandre Detappe
- Hung V.-T. Nguyen
- Jeremiah A. Johnson
