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Showing 1–5 of 5 results
Advanced filters: Author: Sachin Gadani Clear advanced filters

  • A previously unknown mechanism contributes to dysfunction of the neurogenic niche during CNS autoimmunity. Natural killer cells are retained specifically in the subventricular zone in chronic disease, killing stem cells and promoting pathology.

    • Sachin P Gadani
    • Jonathan Kipnis
    News & Views
    Nature Neuroscience
    Volume: 19, P: 176-177

  • Can the immune system influence how our brain works? Here, Jonathan Kipnis and colleagues discuss the emerging hypothesis that T cells, and in particular their production of interleukin–4, can have beneficial effects on learning and memory.

    • Jonathan Kipnis
    • Sachin Gadani
    • Noël C. Derecki
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 12, P: 663-669

  • The mediobasal hypothalamus detects increased amounts of tumor necrosis factor during the early phases of inflammation and relays this information to cells of the adaptive immune system by mobilizing free fatty acids.

    • Sachin P Gadani
    • Jonathan Kipnis
    News & Views
    Nature Immunology
    Volume: 16, P: 440-441

  • Recent evidence suggests that T cells and their derived cytokines affect the brain in disease and health. In this Opinion article, Kipnis and colleagues describe their effects and possible underlying mechanisms, and propose an evolutionary model to explain why the T cell-derived cytokine interferon-γ has both pro-social and immune effects.

    • Anthony J. Filiano
    • Sachin P. Gadani
    • Jonathan Kipnis
    Reviews
    Nature Reviews Neuroscience
    Volume: 18, P: 375-384