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Showing 1–3 of 3 results
Advanced filters: Author: Sachiyo Mitani Clear advanced filters
  • Understanding the genomic features of dedifferentiated liposarcoma (DDLPS) is likely to uncover new options for management. Here, the authors reveal three prognostic groups, and highlight molecular markers associated with malignant transformation.

    • Makoto Hirata
    • Naofumi Asano
    • Koichi Matsuda
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12
  • Mechanisms of acquired resistance to RET tyrosine kinase inhibitors in lung cancers are largely unknown. Here, the authors report in a lung adenocarcinoma patient harboring a CCDC6-RET mutation in the RET kinase (S904F) that results in resistance to the kinase inhibitor vandetanib by increasing the ATP affinity and autophosphorylation activity of RET kinase.

    • Takashi Nakaoku
    • Takashi Kohno
    • Koichi Goto
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9