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Showing 1–6 of 6 results
Advanced filters: Author: Sadra Sadeh Clear advanced filters
  • Neuroscience has inspired artificial intelligence (AI) for decades but, in recent years, AI tools have begun to revolutionize neuroscience research. The emerging field of NeuroAI has the potential to transform large-scale neural modelling and data-driven neuroscience discovery. The field must balance exploiting AI’s power while maintaining interpretability and biological insight.

    • Sadra Sadeh
    • Claudia Clopath
    Comments & Opinion
    Nature Reviews Neuroscience
    Volume: 26, P: 583-584
  • This paper shows that memory engrams are dynamic: neurons drop in and out as engrams become selective during memory consolidation. Inhibition and inhibitory plasticity are crucial for the expression and emergence of memory selectivity, respectively.

    • Douglas Feitosa Tomé
    • Ying Zhang
    • Claudia Clopath
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 561-572
  • Radulescu et al. show that homeostatic mechanisms that reduce cortical activity following overstimulation are dysregulated later in life, such that overstimulation results in synaptic strengthening, elevated activity and cognitive impairment.

    • Carola I. Radulescu
    • Nazanin Doostdar
    • Samuel J. Barnes
    ResearchOpen Access
    Nature Neuroscience
    Volume: 26, P: 2158-2170
  • Systems consolidation refers to the reorganization of memory engrams across brain regions. The authors present a biologically-plausible computational model that shows that hippocampal-thalamic-cortical activity is crucial for systems consolidation, making testable predictions for experimental neuroscience.

    • Douglas Feitosa Tomé
    • Sadra Sadeh
    • Claudia Clopath
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18
  • Single-cell tracing and optogenetics manipulation in mice are used to show how spatial tuning of individual pyramidal cells in CA1 can propagate to and be amplified by their local subnetwork of neurons.

    • Tristan Geiller
    • Sadra Sadeh
    • Attila Losonczy
    Research
    Nature
    Volume: 601, P: 105-109
  • Inhibitory stabilization is a network mechanism that can enable high-gain excitatory networks to operate without leading to runaway activity. Here Sadeh and Clopath review the evidence for inhibition-stabilized networks in the brain and discuss their implications for cortical computation.

    • Sadra Sadeh
    • Claudia Clopath
    Reviews
    Nature Reviews Neuroscience
    Volume: 22, P: 21-37