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Advanced filters: Author: Saeed Arefanian Clear advanced filters

  • High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 therapy.

    • Reza Ghasemi
    • Eric Lazear
    • Alexander Sasha Krupnick
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15