Nature Search

Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

MRI has been used for the non-invasive imaging of human brain aging but is sensitive to both tissue molecular composition and water content. Here the authors present a quantitative MRI method that discriminates these factors and describe region-specific changes in the molecular composition of the aging human brain.

Shir Filo
Oshrat Shtangel
Aviv A. Mezer
ResearchOpen Access30 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Bias towards large genes in autism

Shahar Shohat
Sagiv Shifman
Research06 Aug 2014
Nature

Volume: 512, P: E1-E2
Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice

POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz deficiency in the cerebellum.

Reut Suliman-Lavie
Ben Title
Sagiv Shifman
ResearchOpen Access17 Nov 2020
Nature Communications

Volume: 11, P: 1-15
Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Information on immune receptor repertoire provides important insights on disease progression and therapy development, but can be expensive and time-consuming to obtain. Here the authors report ImReP, a computational method that can extract detailed immune repertoire information from existing tissue-specific RNA sequencing data.

Igor Mandric
Jeremy Rotman
Serghei Mangul
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-14
Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Igor Mandric
Jeremy Rotman
Serghei Mangul
Amendments and CorrectionsOpen Access04 Sept 2020
Nature Communications

Volume: 11, P: 1
Author Correction: Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice

Reut Suliman-Lavie
Ben Title
Sagiv Shifman
Amendments and CorrectionsOpen Access17 Jun 2021
Nature Communications

Volume: 12, P: 1
Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael O'Donovan and colleagues present a genome-wide association study of schizophrenia in 479 cases and 2,937 controls, followed by replication in several cohorts. They report evidence for association for a susceptibility allele near ZNF804A.

Michael C O'Donovan
Nicholas Craddock
Michael J Owen
Research30 Jul 2008
Nature Genetics

Volume: 40, P: 1053-1055
The killifish germline regulates longevity and somatic repair in a sex-specific manner

Moses, Atlan et al. profile the killifish (Nothobranchius furzeri) gonad using single-cell sequencing and reveal that genetic germline depletion induces sexually dimorphic phenotypes, enhancing lifespan in male fish and somatic repair in females.

Eitan Moses
Tehila Atlan
Itamar Harel
Research15 May 2024
Nature Aging

Volume: 4, P: 791-813
The beauty of admixture

Admixture mapping is an old concept that has only now been applied with markers across the entire genome. Such a study scanning an African American population identified two chromosomal regions affecting susceptibility to hypertension.

Ariel Darvasi
Sagiv Shifman
News & Views01 Feb 2005
Nature Genetics

Volume: 37, P: 118-119
The value of isolated populations

Sagiv Shifman
Ariel Darvasi
Correspondence01 Aug 2001
Nature Genetics

Volume: 28, P: 309-310
Strategies for mapping and cloning quantitative trait genes in rodents

Jonathan Flint
William Valdar
Richard Mott
Reviews01 Apr 2005
Nature Reviews Genetics

Volume: 6, P: 271-286
AUTS2 isoforms control neuronal differentiation

Galya Monderer-Rothkoff
Nitzan Tal
Sagiv Shifman
Research05 Apr 2019
Molecular Psychiatry

Volume: 26, P: 666-681
Expansion of the GRIA2 phenotypic representation: a novel de novo loss of function mutation in a case with childhood onset schizophrenia

Anna Alkelai
Shahar Shohat
Yoav Kohn
Research18 Sept 2020
Journal of Human Genetics

Volume: 66, P: 339-343
Gene network analysis reveals a role for striatal glutamatergic receptors in dysregulated risk-assessment behavior of autism mouse models

Oded Oron
Dmitriy Getselter
Evan Elliott
ResearchOpen Access17 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-15
Combined analysis of exome sequencing points toward a major role for transcription regulation during brain development in autism

E Ben-David
S Shifman
Correspondence13 Nov 2012
Molecular Psychiatry

Volume: 18, P: 1054-1056
Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance

J Martin
J Cleak
S Shifman
Correspondence24 Apr 2007
Molecular Psychiatry

Volume: 12, P: 421-422

Search

Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

Bias towards large genes in autism

Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice

Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Author Correction: Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice

Identification of loci associated with schizophrenia by genome-wide association and follow-up

The killifish germline regulates longevity and somatic repair in a sex-specific manner

The beauty of admixture

The value of isolated populations

Strategies for mapping and cloning quantitative trait genes in rodents

AUTS2 isoforms control neuronal differentiation

Expansion of the GRIA2 phenotypic representation: a novel de novo loss of function mutation in a case with childhood onset schizophrenia

Gene network analysis reveals a role for striatal glutamatergic receptors in dysregulated risk-assessment behavior of autism mouse models

Combined analysis of exome sequencing points toward a major role for transcription regulation during brain development in autism

Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance

Search

Quick links

Search

Filter By:

Search

Quick links