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Showing 1–7 of 7 results
Advanced filters: Author: Saharon Rosset Clear advanced filters

  • Population-based genetic studies initially identifiedMYH9as a major susceptibility locus for diabetes-unrelated kidney diseases in persons of West African ancestry, but further research found more strongly associated mutations in the neighboring APOL1 gene. This Review describes how evolutionary selection pressure of an infectious pathogen in West Africa favored the spread of APOL1 variants that protect against a lethal form of African sleeping sickness but are associated with an increased risk of kidney disease. The authors discuss lessons that can be learned for future population genetics research.

    • Saharon Rosset
    • Shay Tzur
    • Karl Skorecki
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 313-326

  • Compared to bulk data, cell-type-specific DNA methylation data provide higher resolution of epigenetic variation. Here, the authors introduce Tensor Composition Analysis, a novel computational approach for learning cell-type-specific DNA methylation from tissue-level bulk data, and show its application in epigenome-wide association studies.

    • Elior Rahmani
    • Regev Schweiger
    • Eran Halperin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Population genetics studies continue to debate whether Ashkenazi Levites originated in Europe or the Near East. Here, Rootsi et al.use whole Y-chromosome DNA sequences to unravel the phylogenetic origin of the Ashkenazi Levite and suggest an origin for the Levite founder lineage in the Near East.

    • Siiri Rootsi
    • Doron M. Behar
    • Peter A. Underhill
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-9

  • Standard approaches for heritability and set testing in statistical genetics rely on parametric models that might not hold in reality and give inflated p-values. Here, the authors develop a fast method for permutation-based testing of marker sets and of heritability that does not suffer from model misspecification.

    • Regev Schweiger
    • Eyal Fisher
    • Eran Halperin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Genomic data from 14 Jewish Diaspora communities are here compared with data from 69 Old World non-Jewish populations, to investigate the demographic history of the Jewish people. Analyses shed new light on relationships between communities, reveal unappreciated genetic substructure within the Middle East, and trace the origins of most Jewish Diaspora communities to the Levant.

    • Doron M. Behar
    • Bayazit Yunusbayev
    • Richard Villems
    Research
    Nature
    Volume: 466, P: 238-242

  • As the virus that causes COVID-19 continues to mutate and spread, new methods are needed to predict new potential variants. Here, the authors identify the best regression models for predicting likely mutation sites in the SARS-CoV-2 genome using a candidate set that considers sequence, gene location, and biological function.

    • Keren Levinstein Hallak
    • Saharon Rosset
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-8