Selective functionalisation of the N-terminus of peptides and proteins may offer a useful tool for single-site modification. Here a general method for selective N-terminal labeling of peptides is reported, based on cyclisation of ethynylbenzaldehyde to form stable isoquinolinium salts.
- Jie-Ren Deng
- Nathanael Chun-Him Lai
- Man-Kin Wong
