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Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes

Altered redox biology causes mitochondrial dysfunction, yet mechanisms and implications vary. Here, the authors identify 15 lipoxygenase-linked mitochondrial ferroptosis and mitophagy driving epithelial cell differentiation and asthma outcomes.

Kazuhiro Yamada
Claudette St. Croix
Sally E. Wenzel
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-17
A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma

Type 2 inflammation drives the formation of pathologic mucus in patients with asthma. Here, authors reveal a role for intelectin-1 in IL-13-induced mucus properties, and that an ITLN1 eQTL is associated with protection from the formation of mucus plugs in T2-high asthma.

Jamie L. Everman
Satria P. Sajuthi
Max A. Seibold
ResearchOpen Access09 May 2024
Nature Communications

Volume: 15, P: 1-17
Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study

The antibody response to COVID-19 vaccines varies among individuals. Here the authors find that older age, male sex, smoking, higher BMI, vaccine type, and certain comorbidities are associated with lower anti-S1 antibody levels after COVID-19 vaccinations, indicating that certain groups might benefit from higher frequency or doses of vaccination.

John S. Kim
Yifei Sun
Elizabeth C. Oelsner
ResearchOpen Access19 Feb 2024
Nature Communications

Volume: 15, P: 1-12
Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Analysis of 97,691 high-coverage human blood DNA-derived whole-genome sequences enabled simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells, indicating that both inherited and acquired mutations are linked to age-related cancers and coronary heart disease.

Alexander G. Bick
Joshua S. Weinstock
Pradeep Natarajan
Research14 Oct 2020
Nature

Volume: 586, P: 763-768
Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma

Recurrent infections with respiratory syncytial virus (RSV) early in life increase susceptibility to asthma. Nandini Krishnamoorthy et al. show that RSV infection of young mice impairs maternally transferred tolerance to allergens. Regulatory T (T_reg) cells in infected mice have impaired suppressor function and adopt a T_H2-like phenotype.

Nandini Krishnamoorthy
Anupriya Khare
Prabir Ray
Research09 Sept 2012
Nature Medicine

Volume: 18, P: 1525-1530
One thousand plant transcriptomes and the phylogenomics of green plants

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

James H. Leebens-Mack
Michael S. Barker
Gane Ka-Shu Wong
ResearchOpen Access23 Oct 2019
Nature

Volume: 574, P: 679-685
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Alexander G. Bick
Joshua S. Weinstock
Pradeep Natarajan
Amendments and Corrections11 Mar 2021
Nature

Volume: 591, P: E27
Asthma phenotypes: the evolution from clinical to molecular approaches

The growing appreciation of asthma as a heterogeneous disease has led to the concept that asthma consists of multiple, different phenotypes, but now the challenge is to link underlying biology to phenotypes to allow a more robust classification and understanding of asthma. This review discusses the progress in defining asthma phenotypes and provides insights into how to apply this knowledge to provide more personalized approaches to treating asthma.

Sally E Wenzel
Reviews04 May 2012
Nature Medicine

Volume: 18, P: 716-725
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

Dan Nicolae, Carole Ober and colleagues report a meta-analysis of genome-wide association studies for asthma in a collection of ethnically diverse North American populations. They identify a newly associated susceptibility locus at PYHIN1 in individuals of African descent.

Dara G Torgerson
Elizabeth J Ampleford
Dan L Nicolae
Research31 Jul 2011
Nature Genetics

Volume: 43, P: 887-892
Asthma

Asthma is a chronic inflammatory disease of the airways. Here, Holgate and colleagues outline the need for a better mechanistic understanding of the origins and heterogeneity of asthma, and discuss how this is leading a move towards more-personalized and targeted treatments.

Stephen T. Holgate
Sally Wenzel
Peter D. Sly
Reviews10 Sept 2015
Nature Reviews Disease Primers

Volume: 1, P: 1-22
Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma

Michelle L. Manni
Victoria A. Heinrich
Stacy G. Wendell
ResearchOpen Access07 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
ATP12A promotes mucus dysfunction during Type 2 airway inflammation

Alison T. Lennox
Stefanie L. Coburn
Mike M. Myerburg
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-13

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