Nature Search

SwiftReg cluster registration automatically reduces flow cytometry data variability including batch effects

Rebhahn et al. develop swiftReg that automatically corrects undesired sources of variability of flow cytometry data. To identify batch variation, this method registers an internal standard or consensus sample from each batch and applies the resulting registration shifts to individual samples, reducing the batch variation while preserving biological differences.

Jonathan A. Rebhahn
Sally A. Quataert
Tim R. Mosmann
ResearchOpen Access07 May 2020
Communications Biology

Volume: 3, P: 1-14
A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1

Graham F. Kay
Alan Ashworth
Sohaila Rastant
Research12 Dec 1991
Nature

Volume: 354, P: 486-489
FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma

Although it has shown high efficacy in many tumor types, interleukin-12 (IL-12) treatment provokes severe systemic toxicity. Here, the authors discover that use of an IL-12Fc fusion cytokine with abolished binding to the neonatal Fc receptor presents efficacy in local glioblastoma therapy while preventing toxicity.

Michal Beffinger
Linda Schellhammer
Johannes vom Berg
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-19
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

Frances Connor
David Bertwistle
Alan Ashworth
Research01 Dec 1997
Nature Genetics

Volume: 17, P: 423-430
Identification of the familial cylindromatosis tumour-suppressor gene

Graham R. Bignell
William Warren
Michael R. Stratton
Research01 Jun 2000
Nature Genetics

Volume: 25, P: 160-165
Identification of the breast cancer susceptibility gene BRCA2

Richard Wooster
Graham Bignell
Michael R. Stratton
Amendments and Corrections22 Feb 1996
Nature

Volume: 379, P: 749
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

Kazuya Shimoda
Jan van Deursent
J. N. Ihle
Research18 Apr 1996
Nature

Volume: 380, P: 630-633
Identification of the breast cancer susceptibility gene BRCA2

Richard Wooster
Graham Bignell
Michael R. Stratton
Research28 Dec 1995
Nature

Volume: 378, P: 789-792
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Tracking the COVID-19 pandemic in Australia using genomics

Genome sequencing can be used to infer pathogen transmission dynamics and inform public health responses. Here, the authors sequence >1,200 SARS-CoV-2 samples from Victoria, Australia and find genomic support for the effectiveness of social restrictions in reducing transmission.

Torsten Seemann
Courtney R. Lane
Benjamin P. Howden
ResearchOpen Access01 Sept 2020
Nature Communications

Volume: 11, P: 1-9
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

FXR regulates the levels of ACE2 in tissues of the respiratory and gastrointestinal systems that are affected by COVID-19, and inhibiting FXR with ursodeoxycholic acid downregulates ACE2 and reduces susceptibility to SARS-CoV-2 infection.

Teresa Brevini
Mailis Maes
Fotios Sampaziotis
ResearchOpen Access05 Dec 2022
Nature

Volume: 615, P: 134-142
Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia

Orouba Almilaji
Sally D. Parry
Jonathon Snook
ResearchOpen Access22 Jun 2021
Scientific Reports

Volume: 11, P: 1-8
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Carer distress among community living older adults with complex needs in the pre- and post-COVID-19 era: a national population study

Philip J. Schluter
Rebecca Abey-Nesbit
Hamish A. Jamieson
ResearchOpen Access16 Nov 2022
Scientific Reports

Volume: 12, P: 1-11

Search

SwiftReg cluster registration automatically reduces flow cytometry data variability including batch effects

A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1

FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

Identification of the familial cylindromatosis tumour-suppressor gene

Identification of the breast cancer susceptibility gene BRCA2

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

Identification of the breast cancer susceptibility gene BRCA2

SARS-CoV-2 evolution during treatment of chronic infection

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Tracking the COVID-19 pandemic in Australia using genomics

Genomic reconstruction of the SARS-CoV-2 epidemic in England

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Carer distress among community living older adults with complex needs in the pre- and post-COVID-19 era: a national population study

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