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Showing 1–3 of 3 results
Advanced filters: Author: Salman Mustfa Clear advanced filters

  • Prime editing can generate undesired editing outcomes. Here, authors describe a method for reducing both on-target and off-target imprecise editing outcomes of diverse prime editing modalities in different cell types with a combination of small molecules that inhibit both DNA-PK and PolΘ activity.

    • Louis C. Dacquay
    • Panagiotis Antoniou
    • Martin Peterka
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • pegRNA scaffold incorporation is a common by-product of prime editing, compromising its precision and safety. Here, the authors show that an internal abasic spacer or 2’-O-methylation within pegRNAs mitigates these by-products by terminating reverse transcriptase before reaching pegRNA scaffold.

    • Panagiotis Antoniou
    • Louis Dacquay
    • Martin Peterka
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Prelithiation can introduce controllable amounts of lithium within porous silicon, however it yields a highly reactive material unsuitable for biomedicine. In this study, the authors present a strategy to lithiate porous silicon nanowires, resulting in a biocompatible and bioresorbable material.

    • Martti Kaasalainen
    • Ran Zhang
    • Ciro Chiappini
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16