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Showing 1–1 of 1 results
Advanced filters: Author: Salome Funes Clear advanced filters
  • Mutations in profilin 1 (PFN1), which modulates actin dynamics, are associated with ALS. Here the authors show that expression of ALS-PFN1 is sufficient to induce deficits in human microglia-like cells, including impaired phagocytosis and lipid metabolism, and that gain-of-function interactions between ALS-PFN1 and PI3P may underlie these deficits.

    • Salome Funes
    • Jonathan Jung
    • Daryl A. Bosco
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25