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Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma

Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment composition independent of changes in clonal composition.

Melissa Barroux
Jacob Househam
Trevor A. Graham
ResearchOpen Access14 May 2025
Nature Cancer

Volume: 6, P: 820-837
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer

A genomic analysis of ductal carcinoma in situ (DCIS) samples with matched ipsilateral invasive breast cancer recurring later shows that around 18% of tumors were unrelated to the DCIS, and had distinct clonal origins.

Esther H. Lips
Tapsi Kumar
Elinor J. Sawyer
ResearchOpen Access09 Jun 2022
Nature Genetics

Volume: 54, P: 850-860
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases

Mario De Piano
Valeria Manuelli
Claire M. Wells
ResearchOpen Access05 Mar 2020
Oncogene

Volume: 39, P: 3666-3679