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Showing 1–4 of 4 results
Advanced filters: Author: Sam E. Tischfield Clear advanced filters

  • Creating accurate models of small cell lung cancer is essential to ensure the clinical relevance of results. Here, the authors create patient derived xenograft models from 33 patients and show, through multi-omics sequencing, that these models retain the primary features of the original.

    • Rebecca Caeser
    • Jacklynn V. Egger
    • Triparna Sen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Small cell lung cancer presents high and multi-site metastatic potential. Here, the authors discover that FOXA2, regulated by ASCL1, promotes multi-site metastasis in small cell lung cancer by inducing a fetal neuroendocrine gene expression program.

    • Kenta Kawasaki
    • Sohrab Salehi
    • Charles M. Rudin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Here, the authors clarify the architecture of genetic risk on chromosome X in three male-biased psychiatric disorders. Leveraging this information they identify an exome-wide significant autism risk gene, MAGEC3, and provide a path forward for future gene discovery on this chromosome.

    • Sheng Wang
    • Belinda Wang
    • A. Jeremy Willsey
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Biochemical and structural characterization of the meiotic DSB core complex of budding yeast reveals molecular architecture and DNA-binding properties similar to those of ancestral Topo VI.

    • Corentin Claeys Bouuaert
    • Sam E. Tischfield
    • Scott Keeney
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 92-102