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Advanced filters: Author: Sam Guoping Gu Clear advanced filters

Reprogramming the piRNA pathway for multiplexed and transgenerational gene silencing in C. elegans

This work presents a piRNA-mediated interference for multiplexed gene silencing in Caenorhabditis elegans.

Monika Priyadarshini
Julie Zhouli Ni
Christian Frøkjær-Jensen
Research03 Feb 2022
Nature Methods

Volume: 19, P: 187-194
A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

Double-stranded RNA interference (RNAi) in Caenorhabditis elegans is heritable; here a genetic screen for factors required for RNAi inheritance identifies the nuclear-localized Argonaute gene hrde-1, which acts in the germ cells of progeny to promote multigenerational inheritance of silencing and, also, germline immortality.

Bethany A. Buckley
Kirk B. Burkhart
Scott Kennedy
Research18 Jul 2012
Nature

Volume: 489, P: 447-451
Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint

Andy Fire and colleagues report the finding of histone H3 lysine 9 trimethylation footprints extending several kilobases from siRNA targets at specific loci across the C. elegans genome. Such exogenous RNA–induced chromatin modification was mediated by secondary amplification of siRNA and was maintained across two or more generations.

Sam Guoping Gu
Julia Pak
Andrew Fire
Research08 Jan 2012
Nature Genetics

Volume: 44, P: 157-164

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