Nature Search

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Mixed responses to targeted therapy within a patient are a clinical challenge. Here the authors show that TP53 loss-of-function cooperates with whole genome doubling which increases chromosomal instability. This leads to greater cellular diversity and multiple routes of resistance, which in turn promotes mixed responses to treatment.

Sebastijan Hobor
Maise Al Bakir
Charles Swanton
ResearchOpen Access13 Jun 2024
Nature Communications

Volume: 15, P: 1-21
Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis

Salvatore Albani
Edward C. Keystone
Dennis A. Carson
Research01 May 1995
Nature Medicine

Volume: 1, P: 448-452
Inhibition of Photo-inactivation of Taka-amylase A by Halogen Ions

GIITI TOMITA
SAM SOON KIM
Research28 Aug 1965
Nature

Volume: 207, P: 975-976
The dynamics of pattern matching in camouflaging cuttlefish

The cuttlefish Sepia officinalis uses high-dimensional skin patterns for camouflage, and the pattern matching process is not stereotyped—each search meanders through skin-pattern space, decelerating and accelerating repeatedly before stabilizing.

Theodosia Woo
Xitong Liang
Gilles Laurent
ResearchOpen Access28 Jun 2023
Nature

Volume: 619, P: 122-128
Wake-like skin patterning and neural activity during octopus sleep

Octopuses possess a distinct active sleep stage, with behavioural and neural correlates resembling vertebrate REM sleep, which may represent convergent features of complex cognition.

Aditi Pophale
Kazumichi Shimizu
Sam Reiter
ResearchOpen Access28 Jun 2023
Nature

Volume: 619, P: 129-134
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
A claustrum in reptiles and its role in slow-wave sleep

A structure homologous to the mammalian claustrum exists in reptiles and has a role in generating sharp waves in the brain during slow-wave sleep.

Hiroaki Norimoto
Lorenz A. Fenk
Gilles Laurent
Research12 Feb 2020
Nature

Volume: 578, P: 413-418
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Elucidating the control and development of skin patterning in cuttlefish

Tracking analyses of tens of thousands of individual chromatophores in freely behaving cephalopods enable studies of behaviour and development at cellular resolution.

Sam Reiter
Philipp Hülsdunk
Gilles Laurent
Research17 Oct 2018
Nature

Volume: 562, P: 361-366
Molecular imaging of cancer with positron emission tomography

Sanjiv Sam Gambhir
Reviews01 Sept 2002
Nature Reviews Cancer

Volume: 2, P: 683-693
Microbiota succession throughout life from the cradle to the grave

The human microbiota can undergo dramatic changes during different phases of life (for example, during colonization after birth, after disturbances or in old age). In this Review, Knight and colleagues discuss the microbiota successions that occur from the cradle to the grave.

Cameron Martino
Amanda Hazel Dilmore
Rob Knight
Reviews29 Jul 2022
Nature Reviews Microbiology

Volume: 20, P: 707-720

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