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Showing 1–7 of 7 results
Advanced filters: Author: Samantha J. Stehbens Clear advanced filters
  • Voltage-gated sodium channels function as multiprotein signaling complexes. Here, authors show that the dispanin TMEM233 is essential for activity of stinging nettle toxins and that co-expression of TMEM233 modulates the gating properties of NaV1.7.

    • Sina Jami
    • Jennifer R. Deuis
    • Irina Vetter
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • Slow-cycling melanoma persister cells are characterised by a high, reversible expression of H3K4 demethylase KDM5B. Here, the authors use genetic and chemical methods to enforce a permanent high expression of KDM5B and show that these cells transit to a melanocytic differentiated state and undergo cell cycle arrest.

    • Heike Chauvistré
    • Batool Shannan
    • Alexander Roesch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17
  • Yap and colleagues identify an extramitotic role for the centralspindlin complex, a Rho signalling regulator during cytokinesis. They show that centralspindlin interacts with α-catenin, and promotes epithelial junctional integrity by recruiting the ECT2 RhoGEF to the zonula adherens, as well as by inhibiting the junctional localization of the p190 B RhoGAP.

    • Aparna Ratheesh
    • Guillermo A. Gomez
    • Alpha S. Yap
    Research
    Nature Cell Biology
    Volume: 14, P: 818-828
  • Wittmann and colleagues demonstrate that the turnover of mature focal adhesions is regulated by CLASP proteins. They show that CLASP recruitment to focal adhesions is involved in localized exocytosis and extracellular matrix degradation, suggesting that local matrix metalloprotease secretion might promote focal adhesion disassembly.

    • Samantha J. Stehbens
    • Matthew Paszek
    • Torsten Wittmann
    Research
    Nature Cell Biology
    Volume: 16, P: 558-570
  • This study shows conserved EAG2 potassium channel function in brain tumorigenesis and metastasis, cooperation of different potassium channels for mitotic volume regulation, and EAG2 enrichment at the trailing edge for local volume regulation and cell motility. The authors identified the FDA-approved drug thioridazine as an EAG2 blocker of potential therapeutic value.

    • Xi Huang
    • Ye He
    • Lily Yeh Jan
    Research
    Nature Neuroscience
    Volume: 18, P: 1236-1246