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Showing 1–7 of 7 results
Advanced filters: Author: Samantha Laber Clear advanced filters

  • Glunk et al. explore target genes and cellular mechanisms related to a metabolic obesity with normal-weight phenotype, and identify a non-coding variant that affects actin remodelling in subcutaneous adipocytes, which in turn affects the capacity of these cells to accumulate lipids.

    • Viktoria Glunk
    • Samantha Laber
    • Melina Claussnitzer
    Research
    Nature Metabolism
    Volume: 5, P: 861-879

  • The identification of genes and enhancers associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) in women highlights variants within Alu retrotransposons. The WHRadjBMI-linked gene SNX10 plays a role in human adipocyte differentiation and diet-induced adipose expansion in female mice.

    • Grace T. Hansen
    • Débora R. Sobreira
    • Marcelo A. Nóbrega
    Research
    Nature Genetics
    Volume: 55, P: 461-470

  • Here, the authors show that IRX3 is a transcriptional master regulator of multiple histone- and chromatin-remodeling enzymes and the SUMOylation pathway in adipocyte precursor cells. IRX3 ablation results in a SUMOylation-dependent switch from adipogenic to osteogenic identity.

    • Jan-Inge Bjune
    • Samantha Laber
    • Simon N. Dankel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-25

  • Mutations in the FTO gene have been linked to obesity. Here, Merkestein et al. provide in vitro and in vivo evidence that FTOdirectly regulates adipogenesis in mice at the stage of mitotic clonal expansion, likely by modulating the expression of the transcription factor RUNX1T1.

    • Myrte Merkestein
    • Samantha Laber
    • Roger D. Cox
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • A single-cell atlas of white adipose tissue from mouse and human reveals diverse cell types and similarities and differences across species and dietary conditions.

    • Margo P. Emont
    • Christopher Jacobs
    • Evan D. Rosen
    Research
    Nature
    Volume: 603, P: 926-933

  • Miscarriage affects around 15% of clinically confirmed pregnancies. Here the authors carry out a large genome-wide association study for sporadic and multiple consecutive miscarriage and suggest links with placental biology.

    • Triin Laisk
    • Ana Luiza G. Soares
    • Cecilia M. Lindgren
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12