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Showing 1–3 of 3 results
Advanced filters: Author: Samer Gnaim Clear advanced filters

  • A perspective is given on how an electrocatalytic approach, inspired by decades of energy storage studies, can be used in the context of efficient cobalt-hydride generation with a variety of applications in modern organic synthesis.

    • Samer Gnaim
    • Adriano Bauer
    • Phil S. Baran
    Research
    Nature
    Volume: 605, P: 687-695

  • The covalent capture of a ligand by its target protein(s) is important for drug-target identification. Now an electrochemically active warhead—diazetidinone—can be leveraged in a chemoproteomics platform for electroaffinity labelling of a ligand’s target protein to afford target-ligand identification in live cells.

    • Yu Kawamata
    • Keun Ah Ryu
    • Phil S. Baran
    Research
    Nature Chemistry
    Volume: 15, P: 1267-1275

  • Excising hydrogen adjacent to a carbonyl group—one of the most basic and widely employed transformations in organic synthesis—is traditionally achieved using metals and/or stoichiometric oxidants. Now, it has been shown that an electrochemically driven approach removes such requirements, resulting in a more sustainable and easily scalable method with wide substrate scope.

    • Samer Gnaim
    • Yusuke Takahira
    • Phil S. Baran
    Research
    Nature Chemistry
    Volume: 13, P: 367-372