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Showing 1–7 of 7 results

Advanced filters: Author: Samson H. Fong Clear advanced filters

Tumor Necrosis Factor-α, Interleukin-1β, and Interleukin-6 Plasma Levels in Neonatal Sepsis

E S J M De Bont
A Martens
L H F M De Leij
Research01 Apr 1993
Pediatric Research

Volume: 33, P: 380-383
Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

Michel Samson
Frédérick Libert
Marc Parmentier
Research22 Aug 1996
Nature

Volume: 382, P: 722-725
Author Correction: A multilineage screen identifies actionable synthetic lethal interactions in human cancers

Samson H. Fong
Brent M. Kuenzi
Trey Ideker
Amendments and Corrections20 Jan 2025
Nature Genetics

Volume: 57, P: 480
A multilineage screen identifies actionable synthetic lethal interactions in human cancers

A framework combining combinatorial CRISPR knockout in breast, lung and oropharyngeal cancer in vitro models with public data identifies synthetic lethal interactions, such as perturbed KDM5C sensitizing cells to PARP7 inhibition.

Samson H. Fong
Brent M. Kuenzi
Trey Ideker
Research18 Nov 2024
Nature Genetics

Volume: 57, P: 154-164
A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors

Ideker and colleagues present NeST-VVN, a deep learning model based on cancer protein assembly data that can be used to predict the response and resistance of cancer cells to CDK4/6 inhibitors.

Sungjoon Park
Erica Silva
Trey Ideker
ResearchOpen Access05 Mar 2024
Nature Cancer

Volume: 5, P: 996-1009
Few-shot learning creates predictive models of drug response that translate from high-throughput screens to individual patients

Ma et al. apply few-shot learning to train a neural network model on cell-line drug-response data, and they subsequently transfer it to distinct biological contexts including different tissues and patient-derived tumor cells and xenografts.

Jianzhu Ma
Samson H. Fong
Trey Ideker
Research25 Jan 2021
Nature Cancer

Volume: 2, P: 233-244
Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation

Kyle Ford
Brenton P. Munson
Trey Ideker
ResearchOpen Access11 May 2023
Scientific Reports

Volume: 13, P: 1-20