Nature Search

Specific inhibition of chromatin-associated poly(A) synthesis in vitro by cordycepin 5′-triphosphate

KATHLEEN M. ROSE
LINN E. BELL
SAMSON T. JACOB
Research12 May 1977
Nature

Volume: 267, P: 178-180
Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related

KATHLEEN M. ROSE
SAMSON T. JACOB
AJIT KUMAR
Research17 May 1979
Nature

Volume: 279, P: 260-262
A comprehensive genetic map of the human genome based on 5,264 microsatellites

Colette Dib
Sabine Fauré
Jean Weissenbach
Research14 Mar 1996
Nature

Volume: 380, P: 152-154
The dual role of helix – loop – helix-zipper protein USF in ribosomal RNA gene transcription in vivo

Asish K Ghosh
Prasun K Datta
Samson T Jacob
Research06 Feb 1997
Oncogene

Volume: 14, P: 589-594
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Distinct rat proteins can recognize CCAAT-homologous sequences of the metallothionein promoter and trans-activate this promoter

Lyudmila P Aniskovitch
Samson T Jacob
Research31 Mar 1998
Oncogene

Volume: 16, P: 1475-1486
Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy

Oncolytic viruses, such as vesicular stomatitis virus (VSV), are a promising class of cancer therapeutics. Here the authors report that a mutation in the CSDE1 gene renders cancer cells resistant to VSV replication and oncolysis, but a mutation-derived escape-associated neoantigen could be exploited for immunotherapy against treatment-resistant tumors.

Timothy Kottke
Jason Tonne
Richard G. Vile
ResearchOpen Access26 Mar 2021
Nature Communications

Volume: 12, P: 1-15
Barren plateaus in variational quantum computing

Barren plateaus are widely considered as one of the main limitations for variational quantum algorithms. This Review summarizes the latest understandings of barren plateaus, indicating its causes, architecture that will suffer from this phenomenon, and discusses strategies that can — and cannot — avoid it.

Martín Larocca
Supanut Thanasilp
M. Cerezo
Reviews26 Mar 2025
Nature Reviews Physics

Volume: 7, P: 174-189
Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix degradation. Here Hadi et al. identify a netrin-1/neogenin-based crosstalk between macrophages and vascular smooth muscle cells (VSMCs), leading to the secretion of the matrix metalloproteinase MMP-3 by VSMCs and subsequent matrix degradation in AAA lesions.

Tarik Hadi
Ludovic Boytard
Bhama Ramkhelawon
ResearchOpen Access27 Nov 2018
Nature Communications

Volume: 9, P: 1-16
The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer

Juan M. Barajas
Ryan Reyes
Kalpana Ghoshal
ResearchOpen Access14 Jun 2018
Scientific Reports

Volume: 8, P: 1-10
Silencing of metallothionein-I gene in mouse lymphosarcoma cells by methylation

Sarmila Majumder
Kalpana Ghoshal
Samson T Jacob
Research18 Nov 1999
Oncogene

Volume: 18, P: 6287-6295
Prior-night sleep predicts next-day symptoms over ten days among military personnel with sleep problems

Emerson M. Wickwire
Jacob Collen
Shuo Chen
ResearchOpen Access01 Oct 2024
npj Biological Timing and Sleep

Volume: 1, P: 1-4
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

A CRISPR/Cas9 genome editing framework has been developed that allows controlled introduction of mono- and bi-allelic sequence changes, and is used to generate induced human pluripotent stem cells with heterozygous and homozygous dominant mutations in amyloid precursor protein and presenilin 1 that have been associated with early onset Alzheimer’s disease.

Dominik Paquet
Dylan Kwart
Marc Tessier-Lavigne
Research27 Apr 2016
Nature

Volume: 533, P: 125-129
Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy

Samson T Jacob
Tasneem Motiwala
Reviews01 Apr 2005
Cancer Gene Therapy

Volume: 12, P: 665-672
Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis

Carmen Corciulo
Cristina M. Castro
Bruce Neil Cronstein
ResearchOpen Access10 Aug 2020
Scientific Reports

Volume: 10, P: 1-16
Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases

Loren D M Pena
Yong-Hui Jiang
Vandana Shashi
Research14 Sept 2017
Genetics in Medicine

Volume: 20, P: 464-469
A comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative

Vandana Shashi
Kelly Schoch
Allison Zheng
Research15 Jun 2018
Genetics in Medicine

Volume: 21, P: 161-172
#InSituPathologists: how the #USCAP2015 meeting went viral on Twitter and founded the social media movement for the United States and Canadian Academy of Pathology

David Cohen
Timothy Craig Allen
Jerad M Gardner
Editorial13 Jan 2017
Modern Pathology

Volume: 30, P: 160-168
An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Sacha Ferdinandusse
Kirsty McWalter
Frédéric M. Vaz
ResearchOpen Access26 Nov 2020
Genetics in Medicine

Volume: 23, P: 740-750
Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain

Felix Marbach
Georgi Stoyanov
Christian P. Schaaf
ResearchOpen Access08 Apr 2021
Genetics in Medicine

Volume: 23, P: 1465-1473
Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

Lance H. Rodan
Rebecca C. Spillmann
Vandana Shashi
Research23 Jun 2021
Genetics in Medicine

Volume: 23, P: 1922-1932
Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs

Recent studies have revealed remarkable complexity in the biogenesis, trafficking and mechanisms of action of small nuclear and small nucleolar ribonucleoproteins (RNPs). The principles of RNP-complex formation can be used to understand the regulation and function of other non-coding RNPs.

A. Gregory Matera
Rebecca M. Terns
Michael P. Terns
Reviews01 Mar 2007
Nature Reviews Molecular Cell Biology

Volume: 8, P: 209-220
Integrative omics framework for characterization of coral reef ecosystems from the Tara Pacific expedition

Caroline Belser
Julie Poulain
Patrick Wincker
ResearchOpen Access01 Jun 2023
Scientific Data

Volume: 10, P: 1-19
Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11

Thomas A. Ravenscroft
Jennifer B. Phillips
Hugo J. Bellen
Research10 Jun 2021
Genetics in Medicine

Volume: 23, P: 1889-1900
Clinical sites of the Undiagnosed Diseases Network: unique contributions to genomic medicine and science

Kelly Schoch
Cecilia Esteves
Vandana Shashi
Research23 Oct 2020
Genetics in Medicine

Volume: 23, P: 259-271
Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases

Shilpa Nadimpalli Kobren
Dustin Baldridge
Isaac S. Kohane
ResearchOpen Access12 Feb 2021
Genetics in Medicine

Volume: 23, P: 1075-1085
Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition

Adriana Alberti
Julie Poulain
Patrick Wincker
ResearchOpen Access01 Aug 2017
Scientific Data

Volume: 4, P: 1-20
PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model

T Motiwala
H Kutay
S T Jacob
Research08 Dec 2014
Leukemia

Volume: 29, P: 1350-1359
Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

Tasneem Motiwala
Kalpana Ghoshal
Christoph Plass
Research25 Sept 2003
Oncogene

Volume: 22, P: 6319-6331
TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

B Wang
S -H Hsu
K Ghoshal
Research21 Dec 2009
Oncogene

Volume: 29, P: 1787-1797
Correction: Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

Lance H. Rodan
Rebecca C. Spillmann
Vandana Shashi
Amendments and Corrections14 Sept 2021
Genetics in Medicine

Volume: 23, P: 2016
One is the loneliest number: genotypic matchmaking using the electronic health record

Elly Brokamp
Mary E. Koziura
Jimann Shin
Comments & Opinion06 Jul 2021
Genetics in Medicine

Volume: 23, P: 1830-1832
Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Sacha Ferdinandusse
Kirsty McWalter
Frédéric M. Vaz
Amendments and CorrectionsOpen Access19 Oct 2021
Genetics in Medicine

Volume: 23, P: 2467

Search

Specific inhibition of chromatin-associated poly(A) synthesis in vitro by cordycepin 5′-triphosphate

Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related

A comprehensive genetic map of the human genome based on 5,264 microsatellites

The dual role of helix – loop – helix-zipper protein USF in ribosomal RNA gene transcription in vivo

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Distinct rat proteins can recognize CCAAT-homologous sequences of the metallothionein promoter and trans-activate this promoter

Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy

Barren plateaus in variational quantum computing

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer

Silencing of metallothionein-I gene in mouse lymphosarcoma cells by methylation

Prior-night sleep predicts next-day symptoms over ten days among military personnel with sleep problems

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy

Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis

Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases

A comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative

#InSituPathologists: how the #USCAP2015 meeting went viral on Twitter and founded the social media movement for the United States and Canadian Academy of Pathology

An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain

Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs

Integrative omics framework for characterization of coral reef ecosystems from the Tara Pacific expedition

Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11

Clinical sites of the Undiagnosed Diseases Network: unique contributions to genomic medicine and science

Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases

Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition

PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model

Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

Correction: Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

One is the loneliest number: genotypic matchmaking using the electronic health record

Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

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