The spontaneous formation of isoaspartate has been well-documented in long-lived proteins as an age-dependent post-translational modification. Here, by using liquid chromatography trapped ion mobility mass spectrometry, the authors report the short-lived neuropeptide galanin in the brain has around 20% in the isoaspartate form which enhances fibril formation.
- Samuel Okyem
- David H. Mast
- Jonathan V. Sweedler
