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Snowflakes

SAMUEL LOCKWOOD
Research03 Mar 1887
Nature

Volume: 35, P: 414
Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

Analysis of community-tested cases of SARS-CoV-2 indicates that the B.1.1.7 variant is not only more transmissible than pre-existing variants, but may also cause more severe illness, and is associated with a higher risk of death.

Nicholas G. Davies
Christopher I. Jarvis
Ruth H. Keogh
Research15 Mar 2021
Nature

Volume: 593, P: 270-274
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery

Michael-Christopher Keogh
Jung-Ae Kim
Nevan J. Krogan
Research20 Nov 2005
Nature

Volume: 439, P: 497-501
Histone H3.3 phosphorylation amplifies stimulation-induced transcription

The histone variant H3.3 is phosphorylated at Ser31 in induced genes, and this selective mark stimulates the histone methyltransferase SETD2 and ejects the ZMYND11 repressor, thus revealing a role for histone phosphorylation in amplifying de novo transcription.

Anja Armache
Shuang Yang
Steven Z. Josefowicz
Research22 Jul 2020
Nature

Volume: 583, P: 852-857
IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist

Kevin Baker
Charlotte O’Donnell
Elizabeth Brint
ResearchOpen Access01 Apr 2022
Oncogene

Volume: 41, P: 2672-2684
The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

Katherine Siminovitch and colleagues show that mice expressing the autoimmune disease–associated Ptpn22 coding variant show thymic and splenic enlargement and lymphocyte and dendritic cell hyperresponsiveness. They further show that the variant promotes degradation of the protein, suggesting that it enhances autoimmune disease risk through a loss-of-function mechanism.

Jinyi Zhang
Naima Zahir
Katherine A Siminovitch
Research14 Aug 2011
Nature Genetics

Volume: 43, P: 902-907
New world goat populations are a genetically diverse reservoir for future use

Tiago do Prado Paim
Danielle Assis Faria
Harvey D. Blackburn
ResearchOpen Access06 Feb 2019
Scientific Reports

Volume: 9, P: 1-12

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Snowflakes

Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery

Histone H3.3 phosphorylation amplifies stimulation-induced transcription

IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

New world goat populations are a genetically diverse reservoir for future use

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