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Showing 1–3 of 3 results
Advanced filters: Author: Samuel M. Poloyac Clear advanced filters

  • The biosynthesis of lipid mediators has not previously been identified in mitochondria. Here, polyunsaturated cardiolipins are shown to be oxidized in the mitochondria by cytochrome c. Subsequent hydrolysis of these oxygenated species generates a variety of oxygenated fatty acids as well as non-oxygenated and oxygenated lyso-cardiolipins. These reactions represent a new biosynthetic pathway for the production of lipid mediators.

    • Yulia Y. Tyurina
    • Samuel M. Poloyac
    • Valerian E. Kagan
    Research
    Nature Chemistry
    Volume: 6, P: 542-552

  • SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models.

    • Jinwei Zhang
    • Mohammad Iqbal H. Bhuiyan
    • Xianming Deng
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17