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Showing 1–3 of 3 results
Advanced filters: Author: Sanda Stankovic Clear advanced filters
  • KIR2DL2 and KIR2DL3 are two inhibitory members of the killer-cell immunoglobulin-like receptors (KIR) family that share a common HLA-I preference in binding HLA from the C1 group. However, it is still unclear to what extent binding and function is equivalent between KIR2DL2 and 2DL3. Here, the authors present the crystal structures of KIR2DL2 and 2DL3 in complex with HLA-C*07:02 and observe differences in HLA-C recognition between KIR2DL2 and 2DL3, which correlates with differences in HLA-C binding preference as they show with mutagenesis and binding studies.

    • Shoeib Moradi
    • Sanda Stankovic
    • Julian P. Vivian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11
  • Although the development of natural killer T cells is a T cell antigen receptor–dependent process, the signaling pathways involved are poorly defined. New data demonstrate that the calcineurin–transcription factor NFAT pathway exerts a critical influence on this process by controlling the transcription factor Egr2.

    • Dale I Godfrey
    • Sanda Stankovic
    • Alan G Baxter
    News & Views
    Nature Immunology
    Volume: 10, P: 231-233